Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus - PubMed (original) (raw)

Review

Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus

Joel N Maslow. Hum Vaccin Immunother. 2017.

Abstract

The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed.

Keywords: DNA vaccine; MERS-CoV; Zika virus; coronavirus; emerging infectious disease; epidemic; epidemiology; flavivirus; vaccine.

PubMed Disclaimer

Cited by

Zika Vaccine Development-Current Progress and Challenges for the Future.
Maslow JN. Maslow JN. Trop Med Infect Dis. 2019 Jul 14;4(3):104. doi: 10.3390/tropicalmed4030104. Trop Med Infect Dis. 2019. PMID: 31337115 Free PMC article. Review.
Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial.
Modjarrad K, Roberts CC, Mills KT, Castellano AR, Paolino K, Muthumani K, Reuschel EL, Robb ML, Racine T, Oh MD, Lamarre C, Zaidi FI, Boyer J, Kudchodkar SB, Jeong M, Darden JM, Park YK, Scott PT, Remigio C, Parikh AP, Wise MC, Patel A, Duperret EK, Kim KY, Choi H, White S, Bagarazzi M, May JM, Kane D, Lee H, Kobinger G, Michael NL, Weiner DB, Thomas SJ, Maslow JN. Modjarrad K, et al. Lancet Infect Dis. 2019 Sep;19(9):1013-1022. doi: 10.1016/S1473-3099(19)30266-X. Epub 2019 Jul 24. Lancet Infect Dis. 2019. PMID: 31351922 Free PMC article. Clinical Trial.
A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice.
Li E, Chi H, Huang P, Yan F, Zhang Y, Liu C, Wang Z, Li G, Zhang S, Mo R, Jin H, Wang H, Feng N, Wang J, Bi Y, Wang T, Sun W, Gao Y, Zhao Y, Yang S, Xia X. Li E, et al. Viruses. 2019 Aug 29;11(9):799. doi: 10.3390/v11090799. Viruses. 2019. PMID: 31470645 Free PMC article.
[Conducting clinical studies during the epidemics of communicable diseases: perspectives of methodology and health economics].
Gong M, Liu L, Wu C, Yang Y, Shen Y, Li J, Lin K, Guo Y, Wei H, Xu Z, Zhu H. Gong M, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Mar 30;40(3):353-357. doi: 10.12122/j.issn.1673-4254.2020.03.11. Nan Fang Yi Ke Da Xue Xue Bao. 2020. PMID: 32376587 Free PMC article. Chinese.
Vaccine against SARS-CoV-2: Challenges and considerations.
Chaube R. Chaube R. Can Commun Dis Rep. 2021 Mar 31;47(3):128-131. doi: 10.14745/ccdr.v47i03a01. eCollection 2021 Mar 31. Can Commun Dis Rep. 2021. PMID: 34012335 Free PMC article.

References

1. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, van Boheemen S, Gopal R, Ballhause M, Bestebroer TM, et al.. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17(39):20285. doi:10.1056/NEJMoa1211721. PMID:23041020 - DOI - PubMed
1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814-20. PMID:23075143 - PubMed
1. Centers for Disease Control and Prevention (CDC) Update: Severe respiratory illness associated with Middle East Respiratory Syndrome coronavirus (MERS-CoV) - worldwide, 2012–2013. MMWR Morb Mortal Wkly Rep. 2013;62(23):480-3. doi:10.7326/M13-2486. PMID:23760190 - DOI - PMC - PubMed
1. Arabi Y, Arifi A, Balkhy H, Najm H, Aldawood A, Ghabashi A, Hawa H, Alothman A, Khaldi A, Al Raiy B. Clinical course and outcomes of critically ill patients with Middle East Respiratory Syndrome coronavirus infection. Ann Intern Med. 2014;160:389-97. PMID:24474051 - PubMed
1. Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, Vuotto F, Goffard A, Behillil S, Enouf V, et al.. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: A report of nosocomial transmission. Lancet. 2013;381(9885):2265-72. doi:10.1016/S0140-6736(13)60982-4. PMID:23727167 - DOI - PMC - PubMed

Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus - PubMed (original) (raw)