Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age - PubMed (original) (raw)
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
P M Stewart et al. Lancet. 1987.
Abstract
The sodium retention associated with liquorice ingestion has been thought to be due to a direct mineralocorticoid effect, despite the fact that it does not seem to occur in patients or animals with severe adrenal insufficiency. This study in seven normal subjects given liquorice showed that sodium retention is associated with a significant change in cortisol metabolism indicating inhibition of 11-beta-hydroxysteroid dehydrogenase (11 beta-OHSD). Congenital deficiency of this enzyme produces a syndrome of apparent mineralocorticoid excess. It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.
Similar articles
- Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man.
Stewart PM, Wallace AM, Atherden SM, Shearing CH, Edwards CR. Stewart PM, et al. Clin Sci (Lond). 1990 Jan;78(1):49-54. doi: 10.1042/cs0780049. Clin Sci (Lond). 1990. PMID: 2153495 - Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
Stewart PM, Corrie JE, Shackleton CH, Edwards CR. Stewart PM, et al. J Clin Invest. 1988 Jul;82(1):340-9. doi: 10.1172/JCI113592. J Clin Invest. 1988. PMID: 3164727 Free PMC article. - Apparent mineralocorticoid excess syndromes.
Shimojo M, Stewart PM. Shimojo M, et al. J Endocrinol Invest. 1995 Jul-Aug;18(7):518-32. doi: 10.1007/BF03349763. J Endocrinol Invest. 1995. PMID: 9221270 Review. - Congenital and acquired syndromes of apparent mineralocorticoid excess.
Edwards CR, Walker BR, Benediktsson R, Seckl JR. Edwards CR, et al. J Steroid Biochem Mol Biol. 1993 Apr;45(1-3):1-5. doi: 10.1016/0960-0760(93)90114-c. J Steroid Biochem Mol Biol. 1993. PMID: 8386930 Review. - The cortisol-cortisone shuttle and hypertension.
Stewart PM, Edwards CR. Stewart PM, et al. J Steroid Biochem Mol Biol. 1991;40(4-6):501-9. doi: 10.1016/0960-0760(91)90269-b. J Steroid Biochem Mol Biol. 1991. PMID: 1958552 Review.
Cited by
- Low Cortisone as a Novel Predictor of the Low-Renin Phenotype.
Tapia-Castillo A, Carvajal CA, Pérez JA, Sandoval A, Allende F, Solari S, Fardella CE. Tapia-Castillo A, et al. J Endocr Soc. 2024 Mar 15;8(6):bvae051. doi: 10.1210/jendso/bvae051. eCollection 2024 Apr 6. J Endocr Soc. 2024. PMID: 38586159 Free PMC article. - Plant vs. Kidney: Evaluating Nephrotoxicity of Botanicals with the Latest Toxicological Tools.
Pearson A, Gafner S, Rider CV, Embry M, Ferguson SS, Mitchell CA. Pearson A, et al. Curr Opin Toxicol. 2022 Dec;32:100371. doi: 10.1016/j.cotox.2022.100371. Epub 2022 Aug 31. Curr Opin Toxicol. 2022. PMID: 36311298 Free PMC article. - Mechanistic insights into the primary and secondary alterations of renal ion and water transport in the distal nephron.
Tabibzadeh N, Crambert G. Tabibzadeh N, et al. J Intern Med. 2023 Jan;293(1):4-22. doi: 10.1111/joim.13552. Epub 2022 Aug 21. J Intern Med. 2023. PMID: 35909256 Free PMC article. Review. - Recurrent Hypokalemia and Adrenal Steroids in Patients With APECED.
Borchers J, Mäkitie O, Jääskeläinen J, Laakso S. Borchers J, et al. Front Endocrinol (Lausanne). 2022 Jun 22;13:904507. doi: 10.3389/fendo.2022.904507. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35813662 Free PMC article. - Severe Hypokalemia and Metabolic Alkalosis Caused by Licorice Discovered During the Treatment of Intraoperative Hypoxemia.
Shibata T, Yoshinuma H, Sugiyama D, Kobayashi O. Shibata T, et al. Cureus. 2022 May 28;14(5):e25432. doi: 10.7759/cureus.25432. eCollection 2022 May. Cureus. 2022. PMID: 35774714 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases