Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl - PubMed (original) (raw)
Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl
J M Connor et al. J Med Genet. 1987 Sep.
Abstract
Linkage analysis was undertaken in six families with tuberous sclerosis (TS) using a restriction fragment length polymorphism detected by v-abl. No recombinants were observed in 13 informative meioses (four phase known) giving a maximum lod score of 3.18 at zero recombination (confidence limits 0 to 0.15). This provides further evidence for the assignment of TS to 9q34 and should facilitate cloning of the structural gene, genetic counselling, and first trimester prenatal diagnosis.
References
- Am J Hum Genet. 1974 Sep;26(5):588-97 - PubMed
- Hum Genet. 1976 Sep 10;34(1):35-43 - PubMed
- Nature. 1982 Dec 23;300(5894):765-7 - PubMed
- Nature. 1983 Nov 17-23;306(5940):239-42 - PubMed
- Mol Cell Biol. 1981 Aug;1(8):731-42 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous