Normal-to-mildly increased albuminuria predicts the risk for diabetic retinopathy in patients with type 2 diabetes - PubMed (original) (raw)

Clinical Trial

Normal-to-mildly increased albuminuria predicts the risk for diabetic retinopathy in patients with type 2 diabetes

Min-Kyung Lee et al. Sci Rep. 2017.

Erratum in

Abstract

Albuminuria is closely associated with diabetic retinopathy (DR), but the precise role of the albumin-to-creatinine ratio (ACR) in screening for DR remains to be determined. This study aimed to investigate an ACR threshold for predicting DR in patients with type 2 diabetes. A cross-sectional study was conducted on 1,102 type 2 diabetes patients, aged ≥30 years and recruited from the Korea National Health and Nutrition Examination Survey, 2010-2011. Participants were grouped by stage of DR: mild-to-moderate nonproliferative DR (NPDR), severe NPDR, and proliferative diabetic retinopathy (PDR). An early morning spot urine sample was obtained for ACR measurement. ROC curve analysis revealed that the optimal cut-off value of ACR for predicting DR was 2.26 mg/mmol (20 μg/mg). The prevalence of ACR ≥ 2.26 mg/mmol tended to increase with severity of DR. The risk for DR in patients with ACR ≥ 2.26 mg/mmol was higher than in those with ACR < 2.26 mg/mmol. The risk for severe NPDR and PDR also increased at ACR ≥ 2.26 mg/mmol. Normal-to-mildly increased albuminuria (an ACR of 2.26 mg/mmol) may predict the risk for DR development and progression in patients with type 2 diabetes.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1

Figure 1

ROC curve of ACR for predicting DR. The AUC for an ACR of 2.26 mg/mmol was 0.634 (95% CI = 0.605–0.663; P < 0.0001).

Figure 2

Figure 2

Distribution of patients with ACR ≥ 2.26 mg/mmol at different DR stages. P for trend < 0.0001.

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