The mitochondrial ATP synthase inhibitor protein binds near the C-terminus of the F1 beta-subunit - PubMed (original) (raw)
The mitochondrial ATP synthase inhibitor protein binds near the C-terminus of the F1 beta-subunit
P J Jackson et al. FEBS Lett. 1988.
Free article
Abstract
The specific, mitochondrial ATP synthase protein (IF1) was covalently cross-linked to its binding site on the catalytic sector of the enzyme (F1-ATPase). The cross-linked complex was selectively cleaved, leaving IF1 intact to facilitate the subsequent purification of the F1 fragment to which IF1 was cross-linked. This fragment was identified by sequence analysis as comprising residues 394-459 on the F1 beta-subunit, near the C-terminus. This finding is discussed in the light of secondary structure predictions for both IF1 and the F1 beta-subunit, and sequence homologies between mitochondrial and other ATP synthases.
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