Cellular and molecular mechanisms of drug dependence - PubMed (original) (raw)

Review

. 1988 Nov 4;242(4879):715-23.

doi: 10.1126/science.2903550.

Affiliations

• PMID: 2903550
• DOI: 10.1126/science.2903550

Review

Cellular and molecular mechanisms of drug dependence

G F Koob et al. Science. 1988.

Abstract

The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

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