PLAZA 4.0: an integrative resource for functional, evolutionary and comparative plant genomics - PubMed (original) (raw)

PLAZA 4.0: an integrative resource for functional, evolutionary and comparative plant genomics

Michiel Van Bel et al. Nucleic Acids Res. 2018.

Abstract

PLAZA (https://bioinformatics.psb.ugent.be/plaza) is a plant-oriented online resource for comparative, evolutionary and functional genomics. The PLAZA platform consists of multiple independent instances focusing on different plant clades, while also providing access to a consistent set of reference species. Each PLAZA instance contains structural and functional gene annotations, gene family data and phylogenetic trees and detailed gene colinearity information. A user-friendly web interface makes the necessary tools and visualizations accessible, specific for each data type. Here we present PLAZA 4.0, the latest iteration of the PLAZA framework. This version consists of two new instances (Dicots 4.0 and Monocots 4.0) providing a large increase in newly available species, and offers access to updated and newly implemented tools and visualizations, helping users with the ever-increasing demands for complex and in-depth analyzes. The total number of species across both instances nearly doubles from 37 species in PLAZA 3.0 to 71 species in PLAZA 4.0, with a much broader coverage of crop species (e.g. wheat, palm oil) and species of evolutionary interest (e.g. spruce, Marchantia). The new PLAZA instances can also be accessed by a programming interface through a RESTful web service, thus allowing bioinformaticians to optimally leverage the power of the PLAZA platform.

© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Figures

Figure 1.

Figure 1.

Data content overview Monocot instance PLAZA 4.0. Species in bold are newly included species compared to previous PLAZA instances. Orphan gene families are single-copy species-specific genes. GO evidence groups are based on the following GO evidence types: Experimental (EXP, IDA, IPI, IMP, IGI, IEP), Computational Reviewed (ISS, ISO, ISA, ISM, IGC, IBA, IBD, IKR, IRD, RCA) and Electronic (TAS, NAS, IC, ND, IEA, NR).

Figure 2.

Figure 2.

New tools and data visualizations. From top to bottom and left to right: (A) JavaScript WGDotPlot, (B) Multiplicon Plot, (C) Interactive Phylogenetics Module. The WGDotPlot shows the inter-species colinear regions between Oryza sativa ssp. Japonica and Zea mays. The Multiplicon Plot shows highly conserved colinearity across the Angiosperms (PLAZA 4.0 Monocot instance). The Interactive Phylogenetics Module was run using family HOM04M002831 as seed with a custom selection of species.

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