Relationships between plasma, CSF and brain tryptophan - PubMed (original) (raw)
Relationships between plasma, CSF and brain tryptophan
G Curzon. J Neural Transm Suppl. 1979.
Abstract
In many circumstances plasma free tryptophan correlated better than plasma total tryptophan with brain tryptophan concentration (immobilization, fasting, acute liver failure, some drugs). Also, using a modified Oldendorf method it was found that changes of plasma tryptophan binding considerably affected brain tryptophan uptake. Usually, changes of plasma tryptophan binding and non-esterified fatty acid concentration were associated. This led either to changes of plasma free and brain tryptophan concentrations (see above) or to "buffering" in which the proportion of plasma tryptophan in the free state changed but not its concentration. The plasma free tryptophan-brain tryptophan relationship was confirmed in rats after portocaval anastomosis or sham operation. In these experiments brain tryptophan changes did not correlate with plasma amino acids competing with tryptophan for transport to the brain. Determinations on plasma, lumbar and ventricular CSF from psychiatric patients suggest that plasma free tryptophan concentration provides an index of CSF tryptophan and 5-hydroxyindoleacetic acid concentrations and hence of 5-hydroxytryptamine turnover in the human central nervous system.
Similar articles
- Tryptophan metabolism in analbuminemic rats.
Emori T, Sugiyama K, Nagase S. Emori T, et al. J Biochem. 1983 Sep;94(3):623-32. doi: 10.1093/oxfordjournals.jbchem.a134402. J Biochem. 1983. PMID: 6196353 - Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans.
Pérez-Cruet J, Chase TN, Murphy DL. Pérez-Cruet J, et al. Nature. 1974 Apr 19;248(5450):693-5. doi: 10.1038/248693a0. Nature. 1974. PMID: 4275348 No abstract available. - Effect of aminophylline on tryptophan and other aromatic amino acids in plasma, brain and other tissues and on brain 5-hydroxytryptamine metabolism.
Curzon G, Fernando JC. Curzon G, et al. Br J Pharmacol. 1976 Dec;58(4):533-45. doi: 10.1111/j.1476-5381.1976.tb08621.x. Br J Pharmacol. 1976. PMID: 137023 Free PMC article. - Control of brain monoamine synthesis by diet and plasma amino acids.
Wurtman RJ, Fernstrom JD. Wurtman RJ, et al. Am J Clin Nutr. 1975 Jun;28(6):638-47. doi: 10.1093/ajcn/28.6.638. Am J Clin Nutr. 1975. PMID: 1093382 Review. - Effects on the diet on brain neurotransmitters.
Fernstrom JD. Fernstrom JD. Metabolism. 1977 Feb;26(2):207-23. doi: 10.1016/0026-0495(77)90057-9. Metabolism. 1977. PMID: 13261 Review.
Cited by
- The role of haem in the regulation of rat liver tryptophan metabolism.
Salter M, Pogson CI. Salter M, et al. Biochem J. 1986 Nov 15;240(1):259-63. doi: 10.1042/bj2400259. Biochem J. 1986. PMID: 3827845 Free PMC article. - The effects of alcohol on laboratory-measured impulsivity after L: -Tryptophan depletion or loading.
Dougherty DM, Marsh DM, Mathias CW, Dawes MA, Bradley DM, Morgan CJ, Badawy AA. Dougherty DM, et al. Psychopharmacology (Berl). 2007 Jul;193(1):137-50. doi: 10.1007/s00213-007-0763-6. Epub 2007 Mar 22. Psychopharmacology (Berl). 2007. PMID: 17377773 - Effects of the haem precursor 5-aminolaevulinate on tryptophan metabolism and disposition in the rat.
Badawy AA, Morgan CJ, Davis NR. Badawy AA, et al. Biochem J. 1987 Nov 15;248(1):293-5. doi: 10.1042/bj2480293. Biochem J. 1987. PMID: 3435445 Free PMC article. - Effect of dialysis on plasma and CSF tryptophan and CSF 5-hydroxyindoleacetic acid in advanced renal disease.
Sullivan PA, Murnaghan D, Callaghan N, Kantamaneni BD, Curzon G. Sullivan PA, et al. J Neurol Neurosurg Psychiatry. 1980 Aug;43(8):739-43. doi: 10.1136/jnnp.43.8.739. J Neurol Neurosurg Psychiatry. 1980. PMID: 6159456 Free PMC article. - L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications.
Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. Richard DM, et al. Int J Tryptophan Res. 2009 Mar 23;2:45-60. doi: 10.4137/ijtr.s2129. Int J Tryptophan Res. 2009. PMID: 20651948 Free PMC article.