Autoimmune Hepatitis - PubMed (original) (raw)

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In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.

2023 Aug 14.

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• PMID: 29083819
• Bookshelf ID: NBK459186

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Autoimmune Hepatitis

Catherine D. Linzay et al.

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Excerpt

Autoimmune hepatitis refers to chronic and progressive inflammation of the liver from an unknown cause. The proposed mechanism for the development of autoimmune hepatitis is thought to be the interplay of genetic predisposition, an environmental trigger, and failure of the native immune system resulting in chronic inflammation of hepatocytes and subsequent fibrosis of the liver. There are two known types of autoimmune hepatitis. Type 1 is distinguished by the presence of anti-smooth muscle antibodies (ASMA) with or without anti-nuclear antibodies (ANA). Type 2 autoimmune hepatitis presents with positive anti-liver/anti-kidney microsome (anti-LMK) type 1 antibodies or anti-liver cytosol (anti-LC) type 1 antibodies.

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Conflict of interest statement

Disclosure: Catherine Linzay declares no relevant financial relationships with ineligible companies.

Disclosure: Bashar Sharma declares no relevant financial relationships with ineligible companies.

Disclosure: Sudha Pandit declares no relevant financial relationships with ineligible companies.

Sections

• Continuing Education Activity
• Introduction
• Etiology
• Epidemiology
• Pathophysiology
• Histopathology
• History and Physical
• Evaluation
• Treatment / Management
• Differential Diagnosis
• Pearls and Other Issues
• Enhancing Healthcare Team Outcomes
• Review Questions
• References

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