Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Lipid Metabolism in Aging Adults - PubMed (original) (raw)

Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Lipid Metabolism in Aging Adults

Weicong Ren et al. Front Aging Neurosci. 2017.

Abstract

Hyperlipidemia, one of the cardiovascular (CV) risk factors, is associated with an increase in the risk for dementia. Repetitive transcranial magnetic stimulation (rTMS) was applied over the right dorsolateral prefrontal cortex (DLPFC) to modulate serum lipid levels in older adults. Participants received 10 sessions of rTMS or sham stimulation intervention within 2 weeks. The serum lipid and thyroid hormone-related endocrine levels were assessed before and after the treatment. We found that rTMS significantly decreased serum lipid levels, including the total cholesterol (CHO) and triglyceride (TG); meanwhile, it also increased the thyroid-stimulating hormone (TSH) as well as thyroxine (T4) levels. This suggests that rTMS modulated the serum lipid metabolism by altering activity in the hypothalamo-pituitary-thyroid (HPT) axis. The trial was registered on the website of Chinese Clinical Trial Registry (http://www.chictr.org.cn).

Keywords: HPT axis; cardiovascular disease; lipid metabolism; older adults; rTMS.

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References

    1. Alexander G. E., DeLong M. R., Strick P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357–381. 10.1146/annurev.neuro.9.1.357 -DOI -PubMed
    1. Åsvold B. O., Bjøro T., Vatten L. J. (2013). Associations of TSH levels within the reference range with future blood pressure and lipid concentrations: 11-year follow-up of the HUNT study. Eur. J. Endocrinol. 169, 73–82. 10.1530/EJE-13-0087 -DOI -PubMed
    1. Barker A. T., Jalinous R., Freeston I. L. (1985). Non-invasive magnetic stimulation of human motor cortex. Lancet 325, 1106–1107. 10.1016/s0140-6736(85)92413-4 -DOI -PubMed
    1. Boekholdt S. M., Titan S. M., Wiersinga W. M., Chatterjee K., Basart D. C., Luben R., et al. (2010). Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study. Clin. Endocrinol. 72, 404–410. 10.1111/j.1365-2265.2009.03640.x -DOI -PubMed
    1. Bohning D., Shastri A., McConnell K., Nahas Z., Lorberbaum J., Roberts D., et al. (1999). A combined TMS/fMRI study of intensity-dependent TMS over motor cortex. Biol. Psychiatry 45, 385–394. 10.1016/s0006-3223(98)00368-0 -DOI -PubMed

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