MODOMICS: a database of RNA modification pathways. 2017 update - PubMed (original) (raw)
. 2018 Jan 4;46(D1):D303-D307.
doi: 10.1093/nar/gkx1030.
Magdalena A Machnicka 1 2, Elzbieta Purta 1, Pawel Piatkowski 1, Blazej Baginski 1, Tomasz K Wirecki 1, Valérie de Crécy-Lagard 3, Robert Ross 4, Patrick A Limbach 4, Annika Kotter 5, Mark Helm 5, Janusz M Bujnicki 1 6
Affiliations
- PMID: 29106616
- PMCID: PMC5753262
- DOI: 10.1093/nar/gkx1030
MODOMICS: a database of RNA modification pathways. 2017 update
Pietro Boccaletto et al. Nucleic Acids Res. 2018.
Abstract
MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. In the current database version, we included the following new features and data: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments; new, machine-friendly system of unified abbreviations for modified nucleoside names; sets of modified tRNA sequences for two bacterial species, updated collection of mammalian tRNA modifications, 19 newly identified modified ribonucleosides and 66 functionally characterized proteins involved in RNA modification. Data from MODOMICS have been linked to the RNAcentral database of RNA sequences. MODOMICS is available at http://modomics.genesilico.pl.
© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.
Figures
Figure 1.
Example of MS/LC data for _N_2,_N_2-dimethylguanosine (m2,2G). The display of a new data type: LC/MS information on the modification detail page.
References
- Grosjean H. Fine-tuning of RNA Functions by Modification and Editing. 2005; Berlin-Heidelberg: Springer-Verlag.
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