Dental stem cells in tooth regeneration and repair in the future - PubMed (original) (raw)

Review

. 2018 Feb;18(2):187-196.

doi: 10.1080/14712598.2018.1402004. Epub 2017 Nov 15.

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Review

Dental stem cells in tooth regeneration and repair in the future

Christian Morsczeck et al. Expert Opin Biol Ther. 2018 Feb.

Abstract

Introduction: Human dental stem cells can be obtained from postnatal teeth, extracted wisdom teeth or exfoliated deciduous teeth. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Therefore, the development of dental tissue regeneration represents a suitable but challenging, target for dental stem cell therapies. Areas covered: Expert opinion:

Areas covered: In this review, the authors provide an overview of human dental stem cells and their properties for regeneration medicine. Numerous preclinical studies have shown that dental stem cells improve bone augmentation and healing of periodontal diseases. Clinical trials are ongoing to validate the clinical feasibility of these approaches. Dental stem cells are also important for basic research.

Expert opinion: Dental stem cells offer numerous advantages for tooth repair and regeneration. Data obtained from different studies are encouraging. In the next few years, investigations on dental stem cells in basic research, pre-clinical research and clinical studies will pave the way to optimizing patient-tailored treatments for repair and regeneration of dental tissues.

Keywords: Dental stem cells; bone regeneration; dental implants; endodontics; periodontitis; tissue engineering.

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