A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells - PubMed (original) (raw)
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells
R M Palmer et al. Biochem Biophys Res Commun. 1989.
Abstract
An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.
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