Epigenetic regulation mechanisms of microRNA expression - PubMed (original) (raw)

Review

. 2017 Dec 20;8(5-6):203-212.

doi: 10.1515/bmc-2017-0024.

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Review

Epigenetic regulation mechanisms of microRNA expression

Sara Morales et al. Biomol Concepts. 2017.

Abstract

MicroRNAs (miRNAs) are single-stranded RNAs of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. They are involved in many physiological and pathological processes, including cell proliferation, apoptosis, development and carcinogenesis. Because of the central role of miRNAs in the regulation of gene expression, their expression needs to be tightly controlled. Here, we summarize the different mechanisms of epigenetic regulation of miRNAs, with a particular focus on DNA methylation and histone modification.

Keywords: CpG islands; DNA methylation; epigenetic regulation; histone modification; microRNAs.

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