Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial - PubMed (original) (raw)

Randomized Controlled Trial

. 2017 Nov 21;7(1):15952.

doi: 10.1038/s41598-017-16159-x.

Sulin Cheng 1 2 3, Can Zhao 5, Shenglong Le 6, Yifan Yang 6, Dandan Ke 5, Na Wu 6, Xiao Tan 6 7, Xiaobo Zhang 6, Xiaming Du 4, Jianqin Sun 8, Renwei Wang 5, Yongyong Shi 9, Ronald J H Borra 10 11, Riitta Parkkola 10, Petri Wiklund 7 12 13, Dajiang Lu 14

Affiliations

Randomized Controlled Trial

Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial

Sulin Cheng et al. Sci Rep. 2017.

Abstract

The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50-65-year fulfilled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n = 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups. Progressive supervised AEx training (60-75% VO2max intensity) was given 2-3 times/week in 30-60 min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet fibre of 12 g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was significantly reduced in the AEx (-24.4%), diet (-23.2%), and AED (-47.9%) groups by contrast to the 20.9% increase in the NI group (p = 0.001 for all) after intervention. However, only AED group significantly decreased HbA1c (-4.4%, p = 0.01) compared with the NI group (-0.6%). Aerobic exercise training combined with fibre-enriched diet can reduce HFC more effectively than either exercise or increased fibre-intake alone in pre-diabetic patients with NAFLD.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1

Figure 1

Study profile. HFC = Hepatic fat content; NAFLD = non-alcoholic fatty liver disease; AEx = aerobic exercise; AED = exercise + diet; NI = no intervention, OGTT = oral glucose tolerance test; TG = glucose; MRS = proton magnetic resonance spectroscopy; DXA = dual X-ray densitometry; M = male; F = female.

Figure 2

Figure 2

Change of hepatic fat content (HFC) after intervention. AEx = aerobic exercise; AED = exercise + diet; NI = no intervention; CI = confident interval.

Figure 3

Figure 3

Change of central body fat mass after intervention. AEx = aerobic exercise; AED = exercise + diet; NI = no intervention; FMwb = fat mass of the whole body; FMandroid = fat mass of the android region; FMgynoid = fat mass of the gynoid region; VAT = visceral adipose tissue; SAT = abdominal subcutaneous adipose tissue. The scan pictures were taken from one of the researchers as quality control during the study.

Figure 4

Figure 4

Change of HbA1c and insulin sensitivity after intervention. AEx = aerobic exercise; AED = exercise + diet; NI = no intervention; CI = confident interval; HBA1c = glycated haemoglobin; ISI = insulin sensitivity index.

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