The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins - PubMed (original) (raw)

. 1989 Mar 5;264(7):4133-7.

Affiliations

• PMID: 2917992

Free article

The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins

P Oquendo et al. J Biol Chem. 1989.

Free article

Abstract

A full length cDNA clone of the platelet-derived growth factor-inducible KC gene has been isolated, sequenced, and expressed in COS cells. Both sequence analysis and expression studies indicate that KC encodes a secretory protein. Sequence analysis shows that, furthermore, the protein encoded by KC belongs to a growing superfamily of inducible proteins with a common ancestral linkage to the platelet alpha-granule proteins, platelet factor 4, and connective tissue-activating peptide III. A computer-generated phylogenetic tree documents interrelationships between KC and six additional members of this peptide superfamily. The KC gene is, in all probability, the murine homologue of a human gene termed "gro." By extension, the KC protein is the murine counterpart of the protein encoded by the gro gene. The gro protein corresponds to a factor described as "melanoma growth-stimulating activity."

PubMed Disclaimer

Similar articles

• Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts.
  Huang S, Paulauskis JD, Kobzik L. Huang S, et al. Biochem Biophys Res Commun. 1992 Apr 30;184(2):922-9. doi: 10.1016/0006-291x(92)90679-f. Biochem Biophys Res Commun. 1992. PMID: 1374243
• Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.
  Iida N, Grotendorst GR. Iida N, et al. Mol Cell Biol. 1990 Oct;10(10):5596-9. doi: 10.1128/mcb.10.10.5596-5599.1990. Mol Cell Biol. 1990. PMID: 2078213 Free PMC article.
• The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein.
  Watanabe K, Konishi K, Fujioka M, Kinoshita S, Nakagawa H. Watanabe K, et al. J Biol Chem. 1989 Nov 25;264(33):19559-63. J Biol Chem. 1989. PMID: 2684956
• Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals.
  Modi WS, Yoshimura T. Modi WS, et al. Mol Biol Evol. 1999 Feb;16(2):180-93. doi: 10.1093/oxfordjournals.molbev.a026101. Mol Biol Evol. 1999. PMID: 10028286
• GRO: a novel chemotactic cytokine.
  Sager R, Haskill S, Anisowicz A, Trask D, Pike MC. Sager R, et al. Adv Exp Med Biol. 1991;305:73-7. doi: 10.1007/978-1-4684-6009-4_9. Adv Exp Med Biol. 1991. PMID: 1755381 Review. No abstract available.

Cited by

• A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.
  Farber JM. Farber JM. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5238-42. doi: 10.1073/pnas.87.14.5238. Proc Natl Acad Sci U S A. 1990. PMID: 2115167 Free PMC article.
• Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury.
  Martins-Green M, Bissell MJ. Martins-Green M, et al. J Cell Biol. 1990 Mar;110(3):581-95. doi: 10.1083/jcb.110.3.581. J Cell Biol. 1990. PMID: 2155240 Free PMC article.
• Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant.
  Luo H, Chaudhuri A, Zbrzezna V, He Y, Pogo AO. Luo H, et al. Mol Cell Biol. 2000 May;20(9):3097-101. doi: 10.1128/MCB.20.9.3097-3101.2000. Mol Cell Biol. 2000. PMID: 10757794 Free PMC article.
• Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis.
  Kim HA, Kim SH, Ko HM, Choi JH, Kim KJ, Oh SH, Cho KO, Choi IW, Im SY. Kim HA, et al. Immunology. 2008 Jul;124(3):428-35. doi: 10.1111/j.1365-2567.2007.02795.x. Epub 2008 Apr 4. Immunology. 2008. PMID: 18397269 Free PMC article.
• Panhematin provides a therapeutic benefit in experimental pancreatitis.
  Habtezion A, Kwan R, Akhtar E, Wanaski SP, Collins SD, Wong RJ, Stevenson DK, Butcher EC, Omary MB. Habtezion A, et al. Gut. 2011 May;60(5):671-9. doi: 10.1136/gut.2010.217208. Epub 2010 Dec 15. Gut. 2011. PMID: 21159893 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)