Developmental control of macrophage function - PubMed (original) (raw)
Review
Developmental control of macrophage function
Johnny Bonnardel et al. Curr Opin Immunol. 2018 Feb.
Abstract
The combination between novel fate-mapping tools and single-cell RNA-sequencing technology has revealed the presence of multiple macrophage progenitors. This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. In this manuscript, we review the potential impact of cellular origin on the function of macrophages. We also highlight the need for novel 'functional fate-mapping' tools that would reveal the history of the functional state of macrophages, rather than their cellular origin, in order to finally study their true plasticity in vivo.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
- Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice.
Li Y, Chen Q, Zheng D, Yin L, Chionh YH, Wong LH, Tan SQ, Tan TC, Chan JK, Alonso S, Dedon PC, Lim B, Chen J. Li Y, et al. J Immunol. 2013 Sep 15;191(6):3192-9. doi: 10.4049/jimmunol.1300742. Epub 2013 Aug 9. J Immunol. 2013. PMID: 23935193 - Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells.
Rosas M, Osorio F, Robinson MJ, Davies LC, Dierkes N, Jones SA, Reis e Sousa C, Taylor PR. Rosas M, et al. Eur J Immunol. 2011 Feb;41(2):356-65. doi: 10.1002/eji.201040962. Epub 2011 Jan 11. Eur J Immunol. 2011. PMID: 21268006 - Fate-Mapping Macrophages: From Ontogeny to Functions.
Ahlback A, Gentek R. Ahlback A, et al. Methods Mol Biol. 2024;2713:11-43. doi: 10.1007/978-1-0716-3437-0_2. Methods Mol Biol. 2024. PMID: 37639113 Review. - Macrophage Fate Mapping.
Xu Y, Schrank PR, Williams JW. Xu Y, et al. Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456. Curr Protoc. 2022. PMID: 35687806 Free PMC article. - Determinants of Resident Tissue Macrophage Identity and Function.
Blériot C, Chakarov S, Ginhoux F. Blériot C, et al. Immunity. 2020 Jun 16;52(6):957-970. doi: 10.1016/j.immuni.2020.05.014. Immunity. 2020. PMID: 32553181 Review.
Cited by
- The Interplay of Tumor Vessels and Immune Cells Affects Immunotherapy of Glioblastoma.
Ghosh M, Lenkiewicz AM, Kaminska B. Ghosh M, et al. Biomedicines. 2022 Sep 15;10(9):2292. doi: 10.3390/biomedicines10092292. Biomedicines. 2022. PMID: 36140392 Free PMC article. Review. - Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections.
Fereig RM, Omar MA, Alsayeqh AF. Fereig RM, et al. Vaccines (Basel). 2022 Dec 6;10(12):2082. doi: 10.3390/vaccines10122082. Vaccines (Basel). 2022. PMID: 36560492 Free PMC article. Review. - Single-Cell RNA Transcriptome Profiling of Liver Cells of Short-Term Alcoholic Liver Injury in Mice.
Cao L, Wu D, Qin L, Tan D, Fan Q, Jia X, Yang M, Zhou T, Feng C, Lu Y, He Y. Cao L, et al. Int J Mol Sci. 2023 Feb 22;24(5):4344. doi: 10.3390/ijms24054344. Int J Mol Sci. 2023. PMID: 36901774 Free PMC article. - Niche signals and transcription factors involved in tissue-resident macrophage development.
T'Jonck W, Guilliams M, Bonnardel J. T'Jonck W, et al. Cell Immunol. 2018 Aug;330:43-53. doi: 10.1016/j.cellimm.2018.02.005. Epub 2018 Feb 13. Cell Immunol. 2018. PMID: 29463401 Free PMC article. Review. - Macrophage regulation of graft-_vs_-host disease.
Hong YQ, Wan B, Li XF. Hong YQ, et al. World J Clin Cases. 2020 May 26;8(10):1793-1805. doi: 10.12998/wjcc.v8.i10.1793. World J Clin Cases. 2020. PMID: 32518770 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources