ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes - PubMed (original) (raw)

ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

Djûke M Brinksma et al. J Abnorm Child Psychol. 2018 Oct.

Abstract

Literature suggests that life stressors predict attention-deficit/hyperactivity disorder (ADHD) symptoms and that this relationship is moderated by the serotonin transporter polymorphism (5-HTTLPR). It is less clear whether, on reverse, ADHD symptoms may influence the risk of exposure to life stressors. Furthermore, the role of life stressors may vary across development depending on the type of life stressor. We used threewave longitudinal data of 1,306 adolescents from the general population and clinicreferred cohort of the TRacking Adolescents' Individual Lives Survey. The 5-HTTLPR genotype (SS, LS, LL), parent-reported ADHD symptoms at three time points (T1: Mage = 11.2; T2: Mage = 13.5; T3: Mage = 16.2 years), and the number of personrelated ('dependent') and environment-related ('independent') life stressors occurring between measurements (T1-T2, T2-T3) were assessed. Using path analyses, we examined bidirectional relations between exposure to these life stressors and ADHD symptoms between the separate waves moderated by 5-HTTLPR status. Exposure to life stressors did not predict ADHD symptoms. Rather, we found that in 5-HTTLPR Sallele homozygotes, ADHD symptoms in middle adolescence (T2) predicted exposure to the number of person-related life stressors later in adolescence (T2-T3, p = 0.001). There was no relation with environment-related life stressors. Our study suggests that S-allele homozygotes with higher levels of ADHD symptoms in middle adolescence are more vulnerable to becoming exposed to person-related ('dependent') life stressors in late adolescence. Findings emphasize the need to be aware of social-emotional adversities that may occur in genetically vulnerable adolescents with ADHD symptoms in the transition into adulthood.

Keywords: 5-HTTLPR; ADHD; Adolescence; Development; Gene-environment interaction; Life stressors.

PubMed Disclaimer

Similar articles

• Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence.
  Brinksma DM, Hoekstra PJ, van den Hoofdakker B, de Bildt A, Buitelaar JK, Hartman CA, Dietrich A. Brinksma DM, et al. J Psychiatr Res. 2017 Jul;90:110-117. doi: 10.1016/j.jpsychires.2017.02.014. Epub 2017 Feb 21. J Psychiatr Res. 2017. PMID: 28259004
• The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder.
  van der Meer D, Hartman CA, Richards J, Bralten JB, Franke B, Oosterlaan J, Heslenfeld DJ, Faraone SV, Buitelaar JK, Hoekstra PJ. van der Meer D, et al. J Child Psychol Psychiatry. 2014 Dec;55(12):1363-71. doi: 10.1111/jcpp.12240. Epub 2014 May 3. J Child Psychol Psychiatry. 2014. PMID: 24797917 Free PMC article.
• ADHD symptoms across adolescence: the role of the family and school climate and the DRD4 and 5-HTTLPR genotype.
  Brinksma DM, Dietrich A, de Bildt A, Buitelaar JK, van den Hoofdakker BJ, Hoekstra PJ, Hartman CA. Brinksma DM, et al. Eur Child Adolesc Psychiatry. 2020 Aug;29(8):1049-1061. doi: 10.1007/s00787-019-01424-3. Epub 2019 Oct 18. Eur Child Adolesc Psychiatry. 2020. PMID: 31628528 Free PMC article.
• A systematic review and meta-analysis examining the interrelationships between chemical and non-chemical stressors and inherent characteristics in children with ADHD.
  Nilsen FM, Tulve NS. Nilsen FM, et al. Environ Res. 2020 Jan;180:108884. doi: 10.1016/j.envres.2019.108884. Epub 2019 Nov 1. Environ Res. 2020. PMID: 31706600 Free PMC article.

Cited by

• Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations.
  Feurer C, McGeary JE, Brick LA, Knopik VS, Carper MM, Palmer RHC, Gibb BE. Feurer C, et al. J Psychopathol Clin Sci. 2022 Jul;131(5):457-466. doi: 10.1037/abn0000757. Epub 2022 Apr 25. J Psychopathol Clin Sci. 2022. PMID: 35467896 Free PMC article.
• A systematic review and Bayesian meta-analysis of 30 years of stress generation research: Clinical, psychological, and sociodemographic risk and protective factors for prospective negative life events.
  Liu RT, Hamilton JL, Boyd SI, Dreier MJ, Walsh RFL, Sheehan AE, Turnamian MR, Workman ARC, Jorgensen SL. Liu RT, et al. Psychol Bull. 2024 Sep;150(9):1021-1069. doi: 10.1037/bul0000431. Epub 2024 Jun 20. Psychol Bull. 2024. PMID: 38900550
• Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.
  Musci RJ, Augustinavicius JL, Volk H. Musci RJ, et al. Curr Psychiatry Rep. 2019 Aug 13;21(9):81. doi: 10.1007/s11920-019-1065-5. Curr Psychiatry Rep. 2019. PMID: 31410638 Free PMC article. Review.
• Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin.
  Qadeer MI, Amar A, Huang YY, Min E, Galfalvy H, Hasnain S, Mann JJ. Qadeer MI, et al. Sci Rep. 2021 Jan 18;11(1):1670. doi: 10.1038/s41598-021-81198-4. Sci Rep. 2021. PMID: 33462318 Free PMC article.

References

1. 1. Child Dev. 2013 Sep-Oct;84(5):1823-39 - PubMed
2. 1. J Abnorm Child Psychol. 2015 Aug;43(6):1119-30 - PubMed
3. 1. Annu Rev Clin Psychol. 2011;7:383-409 - PubMed
4. 1. Br J Psychiatry. 2007 Jan;190:1-3 - PubMed
5. 1. Science. 2002 Jul 19;297(5580):400-3 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information