Liposomal Gd-DTPA: preparation and characterization of relaxivity - PubMed (original) (raw)
Liposomal Gd-DTPA: preparation and characterization of relaxivity
C Tilcock et al. Radiology. 1989 Apr.
Abstract
Gadolinium diethylenetriaminepentaacetic acid (DTPA) has not proved particularly useful for hepatosplenic magnetic resonance imaging. However, by entrapping the Gd-DTPA within lipid vesicles, one may exploit the ability of the reticuloendothelial system to endocytose particulates, permitting passive delivery of contrast agent to the liver and spleen while decreasing the rate of clearance of Gd-DTPA from the vasculature. Liposomes of 70-400 nm diameter containing Gd-DTPA were prepared by a freeze-thaw extrusion process. These exhibited high trapping efficiencies and excellent stability during storage. For all sizes of liposomes, the relaxivity of the entrapped Gd-DTPA was less than that of free Gd-DTPA. Relaxivity varied linearly with the surface-area-to-volume ratio of the liposomes; the smaller the liposomes, the greater the relaxivity. Liposomes containing cholesterol had a lower relaxivity than liposomes without cholesterol. The authors suggest this reflects the decrease in the water permeability coefficient caused by the presence of cholesterol in the liposome membrane.
Similar articles
- Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging.
Unger EC, Winokur T, MacDougall P, Rosenblum J, Clair M, Gatenby R, Tilcock C. Unger EC, et al. Radiology. 1989 Apr;171(1):81-5. doi: 10.1148/radiology.171.1.2928550. Radiology. 1989. PMID: 2928550 - Gadolinium-labeled liposomes: targeted MR contrast agents for the liver and spleen.
Kabalka G, Buonocore E, Hubner K, Moss T, Norley N, Huang L. Kabalka G, et al. Radiology. 1987 Apr;163(1):255-8. doi: 10.1148/radiology.163.1.3454163. Radiology. 1987. PMID: 3454163 - Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: preparation and characterization.
Ogan MD, Schmiedl U, Moseley ME, Grodd W, Paajanen H, Brasch RC. Ogan MD, et al. Invest Radiol. 1987 Aug;22(8):665-71. Invest Radiol. 1987. PMID: 3667174 - Liver. III: Gadolinium-based hepatobiliary contrast agents (Gd-EOB-DTPA and Gd-BOPTA/Dimeg).
Giovagnoni A, Paci E. Giovagnoni A, et al. Magn Reson Imaging Clin N Am. 1996 Feb;4(1):61-72. Magn Reson Imaging Clin N Am. 1996. PMID: 8673717 Review. - MR contrast enhancement of intracranial lesions with Gd-DTPA.
Hesselink JR, Press GA. Hesselink JR, et al. Radiol Clin North Am. 1988 Jul;26(4):873-87. Radiol Clin North Am. 1988. PMID: 3289078 Review.
Cited by
- Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes.
Zhao JM, Har-el YE, McMahon MT, Zhou J, Sherry AD, Sgouros G, Bulte JW, van Zijl PC. Zhao JM, et al. J Am Chem Soc. 2008 Apr 16;130(15):5178-84. doi: 10.1021/ja710159q. Epub 2008 Mar 25. J Am Chem Soc. 2008. PMID: 18361490 Free PMC article. - Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.
Villaraza AJ, Bumb A, Brechbiel MW. Villaraza AJ, et al. Chem Rev. 2010 May 12;110(5):2921-59. doi: 10.1021/cr900232t. Chem Rev. 2010. PMID: 20067234 Free PMC article. Review. No abstract available. - T1 relaxivity of core-encapsulated gadolinium liposomal contrast agents--effect of liposome size and internal gadolinium concentration.
Ghaghada K, Hawley C, Kawaji K, Annapragada A, Mukundan S Jr. Ghaghada K, et al. Acad Radiol. 2008 Oct;15(10):1259-63. doi: 10.1016/j.acra.2008.04.018. Acad Radiol. 2008. PMID: 18790397 Free PMC article. - Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent.
Cheng Z, Al Zaki A, Jones IW, Hall HK Jr, Aspinwall CA, Tsourkas A. Cheng Z, et al. Chem Commun (Camb). 2014 Mar 7;50(19):2502-4. doi: 10.1039/c3cc48939f. Epub 2014 Jan 24. Chem Commun (Camb). 2014. PMID: 24457826 Free PMC article. - Synthesis and characterization of Gd3+-loaded hyaluronic acid-polydopamine nanoparticles as a dual contrast agent for CT and MRI scans.
Shariati A, Ebrahimi T, Babadinia P, Shariati FS, Ahangari Cohan R. Shariati A, et al. Sci Rep. 2023 Mar 18;13(1):4520. doi: 10.1038/s41598-023-31252-0. Sci Rep. 2023. PMID: 36934115 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical