CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain - PubMed (original) (raw)

. 2018 Feb 1;596(3):347-350.

doi: 10.1113/JP274944. Epub 2018 Jan 2.

Affiliations

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

L F Barros et al. J Physiol. 2018.

No abstract available

Keywords: NADH; brain energy metabolism; glucose; glucose transport; glycolysis; lactate; lactate transport; neuron-glia interaction.

PubMed Disclaimer

Figures

Figure 1

Figure 1. Working model of glucose and lactate exchange between astrocytes and neurons

Dashed arrows connect the relevant pathways with the respective published work. For the sake of simplicity, only the main findings of the papers are considered. Please refer to the main text for details. We apologise to authors of relevant work that had to be omitted because of the maximum 30 references allowed by CrossTalk guidelines. GLUT1, GLUT3: glucose transporters GLUT1 and GLUT3; lac channel: lactate channel; MCT2, MCT4: monocarboxylate transporters MCT2 and MCT4; PPP: pentose phosphate pathway; PYR: pyruvate.

Comment in

Similar articles

Cited by

References

    1. Barros LF, Courjaret R, Jakoby P, Loaiza A, Lohr C & Deitmer JW (2009). Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia 57, 962–970. - PubMed
    1. Bittner CX, Valdebenito R, Ruminot I, Loaiza A, Larenas V, Sotelo‐Hitschfeld T, Moldenhauer H, San Martín A, Gutiérrez R, Zambrano M & Barros LF (2011). Fast and reversible stimulation of astrocytic glycolysis by K+ and a delayed and persistent effect of glutamate. J Neurosci 31, 4709–4713. - PMC - PubMed
    1. Bouzier‐Sore AK, Voisin P, Bouchaud V, Bezancon E, Franconi JM & Pellerin L (2006). Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. Eur J Neurosci 24, 1687–1694. - PubMed
    1. Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J & MacVicar BA (2012). Metabolic communication between astrocytes and neurons via bicarbonate‐responsive soluble adenylyl cyclase. Neuron 75, 1094–1104. - PMC - PubMed
    1. Chuquet J, Quilichini P, Nimchinsky EA & Buzsaki G (2010). Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. J Neurosci 30, 15298–15303. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources