Oxidized low-density lipoprotein in inflammation-driven thrombosis - PubMed (original) (raw)

Review

. 2018 Mar;16(3):418-428.

doi: 10.1111/jth.13925. Epub 2018 Jan 24.

Affiliations

Free article

Review

Oxidized low-density lipoprotein in inflammation-driven thrombosis

G Obermayer et al. J Thromb Haemost. 2018 Mar.

Free article

Abstract

Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke, and pulmonary artery embolism. Although platelet activation and activation of the plasmatic coagulation system are the hallmarks of thrombus formation, inflammatory processes and the cellular responses involved are increasingly being recognized as critical modulators of thrombosis. In the context of many chronic inflammatory diseases that are associated with a high thrombotic risk, oxidized lipoproteins represent a prominent sterile trigger of inflammation. Oxidized low-density lipoprotein and its components play a central role in the initiation and progression of atherosclerotic plaques, but also in other processes that lead to thrombotic events. Moreover, dying cells and microvesicles can be decorated with some of the same oxidized lipid components that are found on oxidized lipoproteins, and thereby similar mechanisms of thromboinflammation may also be active in venous thrombosis. In this review, we summarize the current knowledge on how oxidized lipoproteins and components thereof affect the cells and pathways involved in thrombosis.

Keywords: coagulation; inflammation; microvesicles; oxidized LDL; statins; thrombosis.

© 2018 International Society on Thrombosis and Haemostasis.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources