Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome - PubMed (original) (raw)

Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome

Azam Borzoei et al. J Tradit Complement Med. 2017.

Abstract

Background: The objectives of study were to investigate the effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome (PCOS).

Methods: This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients; aged 20-38 years. Subjects in cinnamon (n = 42) and placebo (n = 42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and dietary intake data were gathered at the beginning and at the end of the study. Independent t test, paired t test and analysis of covariance were used to analyze of data.

Results: Cinnamon significantly increased serum total antioxidant capacity (P = 0.005). Malondialdehyde was significantly decreased compared with placebo (P = 0.014). Cinnamon supplementation significantly improved serum level of total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (all P < 0.05). No significant effect was detected on serum triglyceride level.

Conclusions: Cinnamon supplementation improved antioxidant status and serum lipid profile in women with PCOS and may be applicable for reducing PCOS risk factors.

Keywords: Cinnamon; Malondialdehyde; Polycystic ovary syndrome; Serum lipids; Total antioxidant capacity.

PubMed Disclaimer

Figures

Image 1

Graphical abstract

Fig. 1

Fig. 1

Participant's flow diagram.

Fig. 2

Fig. 2

Effects of cinnamon on (A) triglyceride, (B) cholesterol levels, (C) low density lipoprotein and (D) High density lipoprotein. Data were present as means ± SE for 42 PCOS patients in each group. $P < 0.05 for within group comparisons (paired sample t test); *P < 0.05 for between group comparisons (ANCOVA adjusted for baseline value, BMI and energy intake daily).

Similar articles

Cited by

References

    1. Szczuko M., Skowronek M., Zapałowska-Chwyć M., Starczewski A. Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS) Rocz Panstw Zakl Hig. 2016;67:419–426. - PubMed
    1. Ozcan Dag Z., Alpua M., Isik Y., Buturak S.V., Tulmac O.B. The evaluation of temperament and quality of life in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2016;2:1–4. - PubMed
    1. Agarwal A., Aponte-Mellado A., Premkumar B.J., Shaman A., Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49. - PMC - PubMed
    1. Al-kataan M.A., Ibrahim M.A., Al-jammas M.H.H., Shareef Y.S., Sulaiman M.A. Serum antioxidant vitamins changes in women with polycystic ovarian syndrome. J Bahrain Med Sci. 2010;22:68–71.
    1. Liu J., Zhang D. The role of oxidative stress in the pathogenesis of polycystic ovary syndrome. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012;43:187–190. - PubMed

LinkOut - more resources