Regulation of Autophagy by Hepatitis C Virus for Its Replication - PubMed (original) (raw)

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Regulation of Autophagy by Hepatitis C Virus for Its Replication

Linya Wang et al. DNA Cell Biol. 2018 Apr.

Abstract

Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in recent years indicated that this virus could regulate this cellular pathway and use it to enhance its replication. HCV could temporally control the autophagic flux and use the autophagic membranes for the assembly of its RNA replication complex. In this report, we will discuss the biogenesis of autophagosomes induced by HCV and how HCV uses this autophagic pathway for its RNA replication.

Keywords: autophagosomes; autophagy; hepatitis C virus; homotypic fusion; phagophores.

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Conflict of interest statement

No competing financial interests exist.

Figures

<b>FIG. 1.</b>

**FIG. 1.

Illustration of how HCV regulates autophagy. HCV infection induces the localization of ATG5 to the ER and the subsequent formation of phagophores. Phagophores undergo homotypic fusion in a STX7-dependent manner to form autophagosomes. Both phagophores and autophagosomes can support HCV RNA replication. HCV induces RUBICON expression in the early stage of its life cycle to block the fusion of autophagosomes and lysosomes, resulting in the accumulation of autophagosomes that support HCV RNA replication. HCV, hepatitis C virus; ER, endoplasmic reticulum; ATG, autophagy-related protein; STX7, syntaxin 7.

References

    1. Ait-Goughoulte M., Kanda T., Meyer K., Ryerse J.S., Ray R.B., and Ray R. (2008). Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol 82**,** 2241–2249 - PMC - PubMed
    1. Aizaki H., Lee K.J., Sung V.M., Ishiko H., and Lai M.M. (2004). Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts. Virology 324**,** 450–461 - PubMed
    1. Axe E.L., Walker S.A., Manifava M., Chandra P., Roderick H.L., Habermann A., et al. (2008). Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182**,** 685–701 - PMC - PubMed
    1. Chan S.T., Lee J., Narula M., and Ou J.J. (2016). Suppression of host innate immune response by hepatitis C virus via induction of autophagic degradation of TRAF6. J Virol 90**,** 10928–10935 - PMC - PubMed
    1. Chan S.T., and Ou J.J. (2017). Hepatitis C virus-induced autophagy and host innate immune response. Viruses 9**,** pii: - PMC - PubMed

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