A conformational preference parameter to predict helices in integral membrane proteins - PubMed (original) (raw)

Comparative Study

A conformational preference parameter to predict helices in integral membrane proteins

J K Mohana Rao et al. Biochim Biophys Acta. 1986.

Abstract

Assignments were made for helical regions in several integral membrane proteins using an algorithm devised to delineate the transmembrane helices in bacteriorhodopsin (Eur. J. Biochem. 182 (1982) 565-575). A new conformational preference parameter for membrane-buried helices was obtained. The use of this parameter to predict helices in membrane proteins is discussed. When applied to the L and M subunits of Rhodopseudomonas sphaeroides, five helices were predicted, which is consistent with the three-dimensional X-ray crystal structure. Data on signal sequences and amino acid exchanges in membrane proteins are also analysed and discussed

PubMed Disclaimer

Similar articles

• Structural prediction of membrane-bound proteins.
  Argos P, Rao JK, Hargrave PA. Argos P, et al. Eur J Biochem. 1982 Nov 15;128(2-3):565-75. doi: 10.1111/j.1432-1033.1982.tb07002.x. Eur J Biochem. 1982. PMID: 7151796
• Recognition of transmembrane alpha-helical segments with environmental profiles.
  Efremov RG, Vergoten G. Efremov RG, et al. Protein Eng. 1996 Mar;9(3):253-63. doi: 10.1093/protein/9.3.253. Protein Eng. 1996. PMID: 8736492
• The structure of bacteriorhodopsin and its relevance to other membrane proteins.
  Henderson R. Henderson R. Soc Gen Physiol Ser. 1979;33:3-15. Soc Gen Physiol Ser. 1979. PMID: 424783 No abstract available.
• The structural basis of the functioning of bacteriorhodopsin: an overview.
  Ovchinnikov YA, Abdulaev NG, Feigina MY, Kiselev AV, Lobanov NA. Ovchinnikov YA, et al. FEBS Lett. 1979 Apr 15;100(2):219-24. doi: 10.1016/0014-5793(79)80338-5. FEBS Lett. 1979. PMID: 378693 Review. No abstract available.
• The "microassembly" of integral membrane proteins: applications & implications.
  Popot JL, Engelman DM, Zaccai G, de Vitry C. Popot JL, et al. Prog Clin Biol Res. 1990;343:237-62. Prog Clin Biol Res. 1990. PMID: 2198582 Review.

Cited by

• The msp1 beta multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy.
  Barbet AF, Allred DR. Barbet AF, et al. Infect Immun. 1991 Mar;59(3):971-6. doi: 10.1128/iai.59.3.971-976.1991. Infect Immun. 1991. PMID: 1671779 Free PMC article.
• Bacteriophage lysis: mechanism and regulation.
  Young R. Young R. Microbiol Rev. 1992 Sep;56(3):430-81. doi: 10.1128/mr.56.3.430-481.1992. Microbiol Rev. 1992. PMID: 1406491 Free PMC article. Review.
• Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili.
  Nunn D, Bergman S, Lory S. Nunn D, et al. J Bacteriol. 1990 Jun;172(6):2911-9. doi: 10.1128/jb.172.6.2911-2919.1990. J Bacteriol. 1990. PMID: 1971619 Free PMC article.
• Primary structure of xylene monooxygenase: similarities to and differences from the alkane hydroxylation system.
  Suzuki M, Hayakawa T, Shaw JP, Rekik M, Harayama S. Suzuki M, et al. J Bacteriol. 1991 Mar;173(5):1690-5. doi: 10.1128/jb.173.5.1690-1695.1991. J Bacteriol. 1991. PMID: 1999388 Free PMC article.
• Topological analysis of the Rhodobacter capsulatus PucC protein and effects of C-terminal deletions on light-harvesting complex II.
  LeBlanc HN, Beatty JT. LeBlanc HN, et al. J Bacteriol. 1996 Aug;178(16):4801-6. doi: 10.1128/jb.178.16.4801-4806.1996. J Bacteriol. 1996. PMID: 8759841 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database