Human eosinophils and mast cells: Birds of a feather flock together - PubMed (original) (raw)

Review

Human eosinophils and mast cells: Birds of a feather flock together

Piper A Robida et al. Immunol Rev. 2018 Mar.

Abstract

While the origin of the phrase "birds of a feather flock together" is unclear, it has been in use for centuries and is typically employed to describe the phenomenon that people with similar tastes or interests tend to seek each other out and congregate together. In this review, we have co-opted this phrase to compare innate immune cells of related origin, the eosinophil and mast cell, because they very often accumulate together in tissue sites under both homeostatic and inflammatory conditions. To highlight overlapping yet distinct features, their hematopoietic development, cell surface phenotype, mediator release profiles and roles in diseases have been compared and contrasted. What emerges is a sense that these two cell types often interact with each other and their tissue environment to provide synergistic contributions to a variety of normal and pathologic immune responses.

Keywords: cytokines; eosinophils; homeostasis; inflammation; lineage; mast cells; mediators; receptors.

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Conflict of interest statement

Conflict of Interest:

B.S.B. has current or recent consulting or scientific advisory board arrangements with or has received honoraria from Sanofi-Aventis, TEVA, GlaxoSmithKline, AstraZeneca and Allakos, and owns stock in Allakos and Glycomimetics. He receives publication-related royalty payments from Elsevier and UpToDate™ and is a co-inventor on existing Siglec-8-related patents and thus may be entitled to a share of royalties received by Johns Hopkins University on the potential sales of such products. B.S.B. is also a co-founder of Allakos, which makes him subject to certain restrictions under University policy. The terms of this arrangement are being managed by the Johns Hopkins University and Northwestern University in accordance with their conflict of interest policies. The authors have no additional competing financial interests.

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