No strict requirement for eosinophils for bone marrow plasma cell survival - PubMed (original) (raw)

. 2018 May;48(5):815-821.

doi: 10.1002/eji.201747229. Epub 2018 Mar 23.

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No strict requirement for eosinophils for bone marrow plasma cell survival

Alexandra Bortnick et al. Eur J Immunol. 2018 May.

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Abstract

Lasting antibody responses are maintained by long-lived plasma cells, which are thought to lodge in the BM in specialized survival niches. Eosinophils have been reported to function as a critical component of the BM survival niche where they are thought to provide pro-survival signals to nearby plasma cells. Recent study shows that many BM plasma cells are recently generated and chiefly short-lived cells, raising the possibility that rare plasma cell-eosinophil interactions are a rate-limiting step needed to establish lasting humoral immunity. To address these issues, we examined the impact of eosinophil depletion on short- and long-lived BM plasma cells in the context of antibody responses induced by both T-cell dependent and T-cell independent antigens. Surprisingly, our results failed to support a role for eosinophils in either plasma cell generation or survival. These studies included examination of plasma cell frequencies in mice lacking eosinophils either after antibody-mediated depletion, or due to mutation of the GATA1 locus.

Keywords: Antibodies; B cells; Eosinophils; Memory; Plasma cells.

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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