Continuing rise of Type 2 diabetes incidence in children and young people in the UK - PubMed (original) (raw)

Multicenter Study

. 2018 Jun;35(6):737-744.

doi: 10.1111/dme.13609. Epub 2018 Mar 24.

Affiliations

Multicenter Study

Continuing rise of Type 2 diabetes incidence in children and young people in the UK

T P Candler et al. Diabet Med. 2018 Jun.

Abstract

Aims: To estimate the incidence of Type 2 diabetes in children aged <17 years, compare this with similar data 10 years ago, and characterize clinical features at diagnosis in the UK and Republic of Ireland.

Methods: Using the British Paediatric Surveillance Unit reporting framework, cases of Type 2 diabetes diagnosed in children aged <17 years between 1 April 2015 and 30 April 2016 were reported each month.

Results: A total of 106 cases were reported, giving a UK incidence of 0.72/100 000 (95% CI 0.58-0.88). Children from ethnic minorities had significantly higher incidence compared with white children (0.44/100 000) with rates of 2.92/100 000 and 1.67/100 000, in Asian and BACBB (black/African/Caribbean/black British) children respectively. Sixty-seven percent were girls and 81% had a family history of Type 2 diabetes. The mean BMI sd score at diagnosis was 2.89 (2.88, girls; 2.92, boys); 81% were obese. Children of Asian ethnicity had a significantly lower BMI sd score compared with white children (P<0.001). There was a trend in increased incidence from 2005 to 2015, with a rate ratio of 1.35 (95% CI 0.99-1.84), although this was not statistically significant (P=0.062). There was statistical evidence of increased incidence among girls (P=0.03) and children of South-Asian ethnicity (P=0.01) when comparing the 2005 and 2015 surveys.

Conclusions: Type 2 diabetes remains far less common than Type 1 diabetes in childhood in the UK, but the number of cases continues to rise, with significantly increased incidence among girls and South-Asian children over a decade. Female gender, family history, non-white ethnicity and obesity were found to be strongly associated with the condition.

© 2018 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.

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Figures

Figure 1

Figure 1

Flowchart of cases’ classification. D, Duplicate report;

DP

, Duplicate positive (i.e. duplicate of confirmed case);

IRE

, Republic of Ireland;

NP

, No response received

Figure 2

Figure 2

Box‐plots for the

BMI

z‐scores (

sd

scores) of children aged 0–16 years in

UK

, grouped by their ethnicity

Comment in

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