Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response - PubMed (original) (raw)

. 1987 May 1;138(9):2826-30.

PMID: 2952723

Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response

F D Finkelman et al. J Immunol. 1987.

Abstract

The possibility that injection of mice with an affinity-purified goat antibody to mouse IgD (GaM delta) that stimulates polyclonal IgG1 secretion might also stimulate differentiation of B cells into IgE-secreting cells was suggested by the observation that such treatment induces T cells from those mice to secrete a lymphokine, B cell stimulatory factor 1 (BSF-1), that can stimulate both IgG1 and IgE secretion in vitro. Studies described in this paper show that injection of BALB/c mice with 200 to 3200 micrograms of GaM delta greatly increased the quantity of splenic epsilon chain-encoding mRNA, the number of spleen cells with cytoplasmic IgE, and the concentration of serum IgE 7 days after injection. Serum IgE levels obtained in these mice were approximately 100 times baseline levels and were comparable with those found in mice infected with the nematode parasite Nippostrongylus brasiliensis, but were approximately 2000-fold less than the peak serum IgG1 levels induced by GaM delta injection. Both IgE and IgG1 secretion in GaM delta injected mice were T dependent (blocked by anti-L3T4 antibody). These observations are consistent with the hypothesis that BSF-1 may play a role in the in vivo stimulation of IgE secretion and provide an easy to apply model for the investigation of in vivo regulation of IgE responses.

PubMed Disclaimer

Cited by

B cell receptor ligation induces IgE plasma cell elimination.
Wade-Vallance AK, Yang Z, Libang JB, Robinson MJ, Tarlinton DM, Allen CDC. Wade-Vallance AK, et al. J Exp Med. 2023 Apr 3;220(4):e20220964. doi: 10.1084/jem.20220964. Epub 2023 Feb 28. J Exp Med. 2023. PMID: 36880536 Free PMC article.
MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM. Wigton EJ, et al. J Exp Med. 2021 Nov 1;218(11):e20201422. doi: 10.1084/jem.20201422. Epub 2021 Sep 29. J Exp Med. 2021. PMID: 34586363 Free PMC article.
The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking.
Shao WH, Zhen Y, Finkelman FD, Cohen PL. Shao WH, et al. J Autoimmun. 2014 Sep;53:78-84. doi: 10.1016/j.jaut.2014.03.004. Epub 2014 Apr 24. J Autoimmun. 2014. PMID: 24768065 Free PMC article.
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.
Chaplin JW, Kasahara S, Clark EA, Ledbetter JA. Chaplin JW, et al. J Immunol. 2011 Oct 15;187(8):4199-209. doi: 10.4049/jimmunol.1100198. Epub 2011 Sep 14. J Immunol. 2011. PMID: 21918197 Free PMC article.
New insights into the enigma of immunoglobulin D.
Chen K, Cerutti A. Chen K, et al. Immunol Rev. 2010 Sep;237(1):160-79. doi: 10.1111/j.1600-065X.2010.00929.x. Immunol Rev. 2010. PMID: 20727035 Free PMC article. Review.

Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response - PubMed (original) (raw)