Design and implementation of a low-cost, portable OCT system - PubMed (original) (raw)

. 2018 Feb 20;9(3):1232-1243.

doi: 10.1364/BOE.9.001232. eCollection 2018 Mar 1.

Affiliations

Design and implementation of a low-cost, portable OCT system

Sanghoon Kim et al. Biomed Opt Express. 2018.

Abstract

Optical coherence tomography (OCT) is a widely used biomedical imaging tool, primarily in ophthalmology to diagnose and stage retinal diseases. In order to increase access for a wider range of applications and in low resource settings, we developed a portable, low-cost OCT system that has comparable imaging performance to commercially available systems. Here, we present the system design and characterization and compare the system performance to other commercially available OCT systems. In addition, future cost reductions and potential additional applications of the low-cost OCT system are discussed.

Keywords: (170.4500) Optical coherence tomography; (300.6190) Spectrometers; (330.4460) Ophthalmic optics and devices.

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Conflict of interest statement

AW, MC: Lumedica, Inc. (I,C), WJB: Lumedica, Inc. (I,E), BC: Lumedica, Inc. (C)

Figures

Fig. 1

Fig. 1

(a) Schematic of the loop spectrometer. Zemax spot diagram of the loop spectrometer design (b) at 815 nm, (c) at 840 nm and (d) at 860 nm.

Fig. 2

Fig. 2

(a) The measured intensity of the beam scan captured by a camera at the focal plane using two liquid lenses. (b) The spot profile without adjusting focus at the edge of the scan marked by the red circle in (a). (c) The spot profile after refocusing. (d) FWHM spot size measurements at different distance from the center without adjusting focus and with new focus. (e) An example OCT scan of a tape phantom on a business card.

Fig. 3

Fig. 3

(a) The measured intensity of the beam scan at the focal plane using a MEMS mirror and a liquid lens set up. (b) The spot profile without adjusting focus at the edge of the scan marked by the red circle in (a). (c) The spot profile after refocusing. (d) FWHM spot size measurements at different distance from the center without adjusting focus. Using refocusing method, a spot size under 20 μm was achieved across the entire 7 mm FOV.

Fig. 4

Fig. 4

The system schematic using the Arduino for synchronization.

Fig. 5

Fig. 5

(a) The low-cost system engine and (b) top view of the system interior.

Fig. 6

Fig. 6

OCT image of scotch tape using the (a) low-cost OCT system (scale bar, 200 μm) and (b) Wasatch commercial system (scale bar, 100 μm). The difference in scale bar comes from different imaging depth and FOV of the systems.

Fig. 7

Fig. 7

OCT image of (a) a pig cornea, (b) lens and iris, (c) and iridocorneal angle. (d) OCT image of murine skin. The scale bar represents 200 μm. The images shown are 10 frame averages and the depth is given for optical path in air.

Fig. 8

Fig. 8

(a) OCT image of a live mice retina. (b) OCT image of the same mice showing the optical neve head. The image on the right (b) has lower contrast and SNR due to the dehydration of the lens during imaging. The scale bar represents 200 μm in air.

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