Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes - PubMed (original) (raw)
Randomized Controlled Trial
. 2018 Mar 9;359(6380):1151-1156.
doi: 10.1126/science.aao5774.
Feng Zhang 3, Xiaoying Ding 4, Guojun Wu 3, Yan Y Lam 2, Xuejiao Wang 4, Huaqing Fu 3, Xinhe Xue 3, Chunhua Lu 5, Jilin Ma 5, Lihua Yu 5, Chengmei Xu 5, Zhongying Ren 5, Ying Xu 6, Songmei Xu 6, Hongli Shen 6, Xiuli Zhu 6, Yu Shi 7, Qingyun Shen 7, Weiping Dong 4, Rui Liu 3, Yunxia Ling 4, Yue Zeng 8, Xingpeng Wang 8, Qianpeng Zhang 3, Jing Wang 3, Linghua Wang 3, Yanqiu Wu 3, Benhua Zeng 9, Hong Wei 9, Menghui Zhang 3, Yongde Peng 10, Chenhong Zhang 1
Affiliations
- PMID: 29590046
- DOI: 10.1126/science.aao5774
Randomized Controlled Trial
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Liping Zhao et al. Science. 2018.
Abstract
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Comment in
- High-fibre diet beneficial for T2DM.
Leong I. Leong I. Nat Rev Endocrinol. 2018 Jun;14(6):324. doi: 10.1038/s41574-018-0004-6. Nat Rev Endocrinol. 2018. PMID: 29666452 No abstract available. - Targeting gut microbiota with a complex mix of dietary fibers improves metabolic diseases.
Cani PD. Cani PD. Kidney Int. 2019 Jan;95(1):14-16. doi: 10.1016/j.kint.2018.11.012. Kidney Int. 2019. PMID: 30606413 No abstract available.
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