Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein - PubMed (original) (raw)

Comparative Study

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein

T Yoshida et al. Proc Natl Acad Sci U S A. 1987 Oct.

Erratum in

• Proc Natl Acad Sci U S A 1988 Mar;85(6):1967

Abstract

hst is a transforming gene first identified from transformed NIH 3T3 cells that were transfected with DNA of a human stomach cancer. A genomic fragment of hst obtained directly from a human genomic library also has transforming activity. This fragment has a coding sequence identical to that of the hst cDNA prepared from an NIH 3T3 transformant induced by DNA from a stomach cancer. The deduced amino acid sequence of the hst protein is 43%, 38%, and 40% homologous, respectively, to human basic fibroblast growth factor, human acidic fibroblast growth factor, and mouse int-2 protein in selected regions. This suggests that hst encodes a protein related to fibroblast growth factors, which are wide-spectrum mitogens, and to the int-2 protein, a potential oncogene product implicated in murine mammary carcinogenesis.

PubMed Disclaimer

Similar articles

• Molecular biology of the hst-1 gene.
  Sugimura T, Yoshida T, Sakamoto H, Katoh O, Hattori Y, Terada M. Sugimura T, et al. Ciba Found Symp. 1990;150:79-89; discussion 89-98. doi: 10.1002/9780470513927.ch6. Ciba Found Symp. 1990. PMID: 2142645
• Biological significance of the hst-1 gene.
  Terada M, Yoshida T, Sakamoto H, Miyagawa K, Katoh O, Hattori Y, Sugimura T. Terada M, et al. Princess Takamatsu Symp. 1989;20:71-80. Princess Takamatsu Symp. 1989. PMID: 2535108 Review.
• cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.
  Taira M, Yoshida T, Miyagawa K, Sakamoto H, Terada M, Sugimura T. Taira M, et al. Proc Natl Acad Sci U S A. 1987 May;84(9):2980-4. doi: 10.1073/pnas.84.9.2980. Proc Natl Acad Sci U S A. 1987. PMID: 2953031 Free PMC article.
• An unexpected transforming gene in calf-thymus carrier DNA: bovine hst.
  Yu JC, DeSeabra AJ, Wang LM, Fleming TP, Chedid M, Miki T, Heidaran MA. Yu JC, et al. Gene. 1995 Sep 11;162(2):333-4. doi: 10.1016/0378-1119(95)00330-9. Gene. 1995. PMID: 7557455
• Biological significance of gene amplification in carcinogenesis.
  Terada M, Sakamoto H, Ohmura Y, Tsuruta H, Akiyama N, Sasaki H, Katoh M, Hattori Y, Yoshida T. Terada M, et al. Princess Takamatsu Symp. 1991;22:371-80. Princess Takamatsu Symp. 1991. PMID: 1844251 Review.

Cited by

• Heparin-binding growth factors and their receptors.
  Olwin BB. Olwin BB. Cytotechnology. 1989 Dec;2(4):351-65. doi: 10.1007/BF00364998. Cytotechnology. 1989. PMID: 22358874
• Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma.
  Arnold A, Kim HG, Gaz RD, Eddy RL, Fukushima Y, Byers MG, Shows TB, Kronenberg HM. Arnold A, et al. J Clin Invest. 1989 Jun;83(6):2034-40. doi: 10.1172/JCI114114. J Clin Invest. 1989. PMID: 2723071 Free PMC article.
• Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells.
  Friesel R, Burgess WH, Maciag T. Friesel R, et al. Mol Cell Biol. 1989 May;9(5):1857-65. doi: 10.1128/mcb.9.5.1857-1865.1989. Mol Cell Biol. 1989. PMID: 2473389 Free PMC article.
• A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas.
  Talarico D, Ittmann MM, Bronson R, Basilico C. Talarico D, et al. Mol Cell Biol. 1993 Apr;13(4):1998-2010. doi: 10.1128/mcb.13.4.1998-2010.1993. Mol Cell Biol. 1993. PMID: 8455594 Free PMC article.
• Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.
  Smith R, Peters G, Dickson C. Smith R, et al. EMBO J. 1988 Apr;7(4):1013-22. doi: 10.1002/j.1460-2075.1988.tb02908.x. EMBO J. 1988. PMID: 2841106 Free PMC article.

References

1. 1. J Biol Chem. 1986 Apr 25;261(12):5631-7 - PubMed
2. 1. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2448-52 - PubMed
3. 1. Nature. 1986 May 15-21;321(6067):209-13 - PubMed
4. 1. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3997-4001 - PubMed
5. 1. EMBO J. 1986 May;5(5):919-24 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource