High Glycemic Index Metabolic Damage - a Pivotal Role of GIP and GLP-1 - PubMed (original) (raw)
Review
. 2018 May;29(5):289-299.
doi: 10.1016/j.tem.2018.03.003. Epub 2018 Mar 27.
Affiliations
- PMID: 29602522
- DOI: 10.1016/j.tem.2018.03.003
Free article
Review
High Glycemic Index Metabolic Damage - a Pivotal Role of GIP and GLP-1
Andreas F H Pfeiffer et al. Trends Endocrinol Metab. 2018 May.
Free article
Abstract
When glucose-fructose dimers are supplied as the slowly digestible, completely absorbable, low glycemic index (GI) sugar isomaltulose, the detrimental effects of high GI sucrose are avoided. This difference requires the presence of intact glucose-induced insulinotropic peptide receptor (GIPR) and is mediated by the rapid uptake of glucose and the stimulation of GIP release from K cells in the upper small intestine. GIP promotes lipogenesis, fatty liver, insulin resistance, and postprandial inflammation, and reduces fat oxidation in skeletal muscle, partly by hypothalamic interference with energy partitioning and epigenetic programming. GIP is similarly required for the detrimental metabolic effects of other high GI carbohydrates. We therefore propose that the release of GIP in the upper small intestine is an important determinant of the metabolic quality of carbohydrates.
Keywords: glucose-induced insulinotropic peptide; glycemic index; incretin; isomaltulose; saccharose.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Similar articles
- Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves.
Mayer F, Gunawan AL, Tso P, Aponte GW. Mayer F, et al. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G23-G35. doi: 10.1152/ajpgi.00189.2019. Epub 2020 May 18. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32421358 Free PMC article. - Effects of chronic exposure of clonal β-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1.
Pathak V, Vasu S, Flatt PR, Irwin N. Pathak V, et al. Diabetes Obes Metab. 2014 Apr;16(4):357-65. doi: 10.1111/dom.12227. Epub 2013 Nov 20. Diabetes Obes Metab. 2014. PMID: 24164718 - Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction.
Keyhani-Nejad F, Barbosa Yanez RL, Kemper M, Schueler R, Pivovarova-Ramich O, Rudovich N, Pfeiffer AFH. Keyhani-Nejad F, et al. Peptides. 2020 Mar;125:170231. doi: 10.1016/j.peptides.2019.170231. Epub 2019 Dec 20. Peptides. 2020. PMID: 31870938 Clinical Trial. - Novel extrapancreatic effects of incretin.
Yamada Y, Tsukiyama K, Sato T, Shimizu T, Fujita H, Narita T. Yamada Y, et al. J Diabetes Investig. 2016 Apr;7 Suppl 1(Suppl 1):76-9. doi: 10.1111/jdi.12495. Epub 2016 Mar 31. J Diabetes Investig. 2016. PMID: 27186360 Free PMC article. Review. - Roles of glucose-dependent insulinotropic polypeptide in diet-induced obesity.
Seino Y, Yamazaki Y. Seino Y, et al. J Diabetes Investig. 2022 Jul;13(7):1122-1128. doi: 10.1111/jdi.13816. Epub 2022 May 11. J Diabetes Investig. 2022. PMID: 35452190 Free PMC article. Review.
Cited by
- The Impact of Gastrointestinal Hormones on Human Adipose Tissue Function.
Radziszewska M, Ostrowska L, Smarkusz-Zarzecka J. Radziszewska M, et al. Nutrients. 2024 Sep 25;16(19):3245. doi: 10.3390/nu16193245. Nutrients. 2024. PMID: 39408213 Free PMC article. Review. - Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease.
Dong TS, Katzka W, Yang JC, Chang C, Arias-Jayo N, Lagishetty V, Balioukova A, Chen Y, Dutson E, Li Z, Mayer EA, Pisegna JR, Sanmiguel C, Jacobs JP. Dong TS, et al. Gut Microbes. 2023 Jan-Dec;15(1):2167170. doi: 10.1080/19490976.2023.2167170. Gut Microbes. 2023. PMID: 36732495 Free PMC article. - S100 proteins in obesity: liaisons dangereuses.
Riuzzi F, Chiappalupi S, Arcuri C, Giambanco I, Sorci G, Donato R. Riuzzi F, et al. Cell Mol Life Sci. 2020 Jan;77(1):129-147. doi: 10.1007/s00018-019-03257-4. Epub 2019 Jul 30. Cell Mol Life Sci. 2020. PMID: 31363816 Free PMC article. Review. - Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study.
Angarita Dávila L, Bermúdez V, Aparicio D, Céspedes V, Escobar MC, Durán-Agüero S, Cisternas S, de Assis Costa J, Rojas-Gómez D, Reyna N, López-Miranda J. Angarita Dávila L, et al. Nutrients. 2019 Jun 28;11(7):1477. doi: 10.3390/nu11071477. Nutrients. 2019. PMID: 31261732 Free PMC article. Clinical Trial. - The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
Ludwig DS, Aronne LJ, Astrup A, de Cabo R, Cantley LC, Friedman MI, Heymsfield SB, Johnson JD, King JC, Krauss RM, Lieberman DE, Taubes G, Volek JS, Westman EC, Willett WC, Yancy WS, Ebbeling CB. Ludwig DS, et al. Am J Clin Nutr. 2021 Dec 1;114(6):1873-1885. doi: 10.1093/ajcn/nqab270. Am J Clin Nutr. 2021. PMID: 34515299 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources