Macrophage-Targeted Therapeutics for Metabolic Disease - PubMed (original) (raw)

Review

Macrophage-Targeted Therapeutics for Metabolic Disease

Kristin R Peterson et al. Trends Pharmacol Sci. 2018 Jun.

Abstract

Macrophages are cells of the innate immune system that are resident in all tissues, including metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic flexibility, they play beneficial roles in tissue homeostasis, but they also contribute to the progression of metabolic disease. Thus, they are ideal therapeutic targets for diseases such as insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. Recently, discoveries in the area of drug delivery have facilitated phenotype-specific targeting of macrophages. In this review we discuss advances in potential therapeutics for metabolic diseases via macrophage-specific delivery. We highlight micro- and nanoparticles, liposomes, and oligopeptide complexes, and how they can be used to alter macrophage phenotype for a more metabolically favorable tissue environment.

Keywords: liposome; macrophage; metabolic disease; nanoparticle; obesity; therapeutics.

Published by Elsevier Ltd.

PubMed Disclaimer

References

    1. Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541(7637):321–330. - PubMed
    1. Zlatanova I, et al. Immune Modulation of Cardiac Repair and Regeneration: The Art of Mending Broken Hearts. Front Cardiovasc Med. 2016;3:40. - PMC - PubMed
    1. Sanmarco LM, et al. New Insights into the Immunobiology of Mononuclear Phagocytic Cells and Their Relevance to the Pathogenesis of Cardiovascular Diseases. Front Immunol. 2017;8:1921. - PMC - PubMed
    1. Hill AA, et al. A decade of progress in adipose tissue macrophage biology. Immunol Rev. 2014;262(1):134–52. - PMC - PubMed
    1. Clark M, et al. Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response. Front Immunol. 2017;8:1898. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources