The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites - PubMed (original) (raw)

. 1988 Mar 4;239(4844):1150-3.

doi: 10.1126/science.2964084.

Affiliations

• PMID: 2964084
• DOI: 10.1126/science.2964084

The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites

B R Franza Jr et al. Science. 1988.

Abstract

The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.

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