Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? - PubMed (original) (raw)
. 2019 Jan;187(1):128-136.
doi: 10.1007/s12011-018-1351-9. Epub 2018 Apr 21.
Affiliations
- PMID: 29679349
- DOI: 10.1007/s12011-018-1351-9
Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?
Nazan Uysal et al. Biol Trace Elem Res. 2019 Jan.
Abstract
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues. Following a single dose 400 mg/70 kg magnesium administration to Sprague Dawley rats, bioavailability was evaluated by examining time-dependent absorption, tissue penetration, and the effects on the behavior of the animals. Pharmacokinetically, the area under the curve calculation is highest in the magnesium malate. The magnesium acetyl taurate was found to have the second highest area under the curve calculation. Magnesium acetyl taurate was rapidly absorbed, able to pass through to the brain easily, had the highest tissue concentration level in the brain, and was found to be associated with decreased anxiety indicators. Magnesium malate levels remained high for an extended period of time in the serum. The commonly prescribed dietary supplements magnesium oxide and magnesium citrate had the lowest bioavailability when compared to our control group. More research is needed to investigate the bioavailability of magnesium malate and acetyl taurate compounds and their effects in specific tissues and on behavior.
Keywords: Anxiety; Brain; Magnesium acetyl taurate; Magnesium citrate; Magnesium malate; Magnesium oxide; Magnesium sulfate; Muscle.
Similar articles
- Dose-Dependent Absorption Profile of Different Magnesium Compounds.
Ates M, Kizildag S, Yuksel O, Hosgorler F, Yuce Z, Guvendi G, Kandis S, Karakilic A, Koc B, Uysal N. Ates M, et al. Biol Trace Elem Res. 2019 Dec;192(2):244-251. doi: 10.1007/s12011-019-01663-0. Epub 2019 Feb 13. Biol Trace Elem Res. 2019. PMID: 30761462 - Bioavailability of US commercial magnesium preparations.
Firoz M, Graber M. Firoz M, et al. Magnes Res. 2001 Dec;14(4):257-62. Magnes Res. 2001. PMID: 11794633 - [Effects of magnesium supplementation on calcium and magnesium levels, and redox homeostasis in normolipidemic and food-induced hyperlipidemic rats].
Virág V, May Z, Kocsis I, Blázovics A, Szentmihályi K. Virág V, et al. Orv Hetil. 2011 Jul 3;152(27):1075-81. doi: 10.1556/OH.2011.29152. Orv Hetil. 2011. PMID: 21676674 Hungarian. - Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water.
Willhite CC, Ball GL, McLellan CJ. Willhite CC, et al. Crit Rev Toxicol. 2012 May;42(5):358-442. doi: 10.3109/10408444.2012.674101. Crit Rev Toxicol. 2012. PMID: 22512666 Review. - Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.
Ranade VV, Somberg JC. Ranade VV, et al. Am J Ther. 2001 Sep-Oct;8(5):345-57. doi: 10.1097/00045391-200109000-00008. Am J Ther. 2001. PMID: 11550076 Review.
Cited by
- Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, Braun CA, Xue B, Lin HC. Coffman CN, et al. Microorganisms. 2024 Jul 14;12(7):1429. doi: 10.3390/microorganisms12071429. Microorganisms. 2024. PMID: 39065198 Free PMC article. - Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
Wang S, Zhang J, Zhu T, Xie X, Xia X, Li Y. Wang S, et al. Alpha Psychiatry. 2024 Mar 1;25(2):243-248. doi: 10.5152/alphapsychiatry.2024.231342. eCollection 2024 Mar. Alpha Psychiatry. 2024. PMID: 38798818 Free PMC article. - Magnesium Deficiency and Cardiometabolic Disease.
Fritzen R, Davies A, Veenhuizen M, Campbell M, Pitt SJ, Ajjan RA, Stewart AJ. Fritzen R, et al. Nutrients. 2023 May 17;15(10):2355. doi: 10.3390/nu15102355. Nutrients. 2023. PMID: 37242238 Free PMC article. Review. - Physiology of a Forgotten Electrolyte-Magnesium Disorders.
Ray E, Mohan K, Ahmad S, Wolf MTF. Ray E, et al. Adv Kidney Dis Health. 2023 Mar;30(2):148-163. doi: 10.1053/j.akdh.2022.12.001. Adv Kidney Dis Health. 2023. PMID: 36868730 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources