Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway - PubMed (original) (raw)
. 2018 Aug 1:348:184-191.
doi: 10.1016/j.bbr.2018.04.025. Epub 2018 Apr 20.
Affiliations
- PMID: 29680784
- DOI: 10.1016/j.bbr.2018.04.025
Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway
Yan-Jiao Li et al. Behav Brain Res. 2018.
Abstract
Classic antidepressants benefit depression patients partially by improving neurogenesis and/or brain-derived neurotrophic factor (BDNF)/TrkB pathway which were impaired in depression. In this study, we demonstrated that Silibinin (SLB), a polyphenolic flavanoid from Silybum marianum, ameliorated reserpinized mouse depressant-like behaviors. The antidepressants of SLB administration was associated with increased neural stem cells (NSCs) proliferation and further confirmed in BDNF/TrkB signaling transduction. SLB treatment reversed the decreased expression levels of BDNF and its receptor TrkB, and the reduced activation of downstream target proteins including phosphorylated extracellular-regulated protein kinase (p-ERK) and phosphorylated cAMP-response element binding protein (p-CREB) in depressived hippocampus. Furthermore, intracerebroventricular injection of GNF5837, a TrkB antagonist, abrogated antidepressant-like effects of SLB in mice along with the improved NSC proliferation, as well as enhanced levels of p-ERK and p-CREB in mice hippocampus. Taken together, these results suggest that SLB may exert antidepressant effects through BDNF/TrkB signaling pathway to improve NSC proliferation in acute depression.
Keywords: Acute depression; Brain-derived neurotrophic factor; Neural stem cell; Neurogenesis; Silibinin; TrkB.
Copyright © 2018 Elsevier B.V. All rights reserved.
Similar articles
- The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF/TrkB/CREB signaling pathway.
Lin P, Wang C, Xu B, Gao S, Guo J, Zhao X, Huang H, Zhang J, Chen X, Wang Q, Zhou W. Lin P, et al. Pharmacol Biochem Behav. 2014 May;120:140-8. doi: 10.1016/j.pbb.2014.03.003. Epub 2014 Mar 11. Pharmacol Biochem Behav. 2014. PMID: 24631486 - SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
Jiang B, Wang F, Yang S, Fang P, Deng ZF, Xiao JL, Hu ZL, Chen JG. Jiang B, et al. Int J Neuropsychopharmacol. 2014 Dec 7;18(6):pyu096. doi: 10.1093/ijnp/pyu096. Int J Neuropsychopharmacol. 2014. PMID: 25522427 Free PMC article. - Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors.
Xiao D, Liu L, Li Y, Ruan J, Wang H. Xiao D, et al. Neurochem Res. 2019 Sep;44(9):2044-2056. doi: 10.1007/s11064-019-02840-2. Epub 2019 Jul 5. Neurochem Res. 2019. PMID: 31278631 - TrkB neurotrophin receptor at the core of antidepressant effects, but how?
Rantamäki T. Rantamäki T. Cell Tissue Res. 2019 Jul;377(1):115-124. doi: 10.1007/s00441-018-02985-6. Epub 2019 Jan 12. Cell Tissue Res. 2019. PMID: 30637517 Review. - Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies.
Kozisek ME, Middlemas D, Bylund DB. Kozisek ME, et al. Pharmacol Ther. 2008 Jan;117(1):30-51. doi: 10.1016/j.pharmthera.2007.07.001. Epub 2007 Aug 15. Pharmacol Ther. 2008. PMID: 17949819 Review.
Cited by
- Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics.
Fang S, Wu Z, Guo Y, Zhu W, Wan C, Yuan N, Chen J, Hao W, Mo X, Guo X, Fan L, Li X, Chen J. Fang S, et al. Front Immunol. 2023 Oct 10;14:1193053. doi: 10.3389/fimmu.2023.1193053. eCollection 2023. Front Immunol. 2023. PMID: 37881439 Free PMC article. Review. - Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic-ischemic neonatal rats.
Chen X, Chen A, Wei J, Huang Y, Deng J, Chen P, Yan Y, Lin M, Chen L, Zhang J, Huang Z, Zeng X, Gong C, Zheng X. Chen X, et al. CNS Neurosci Ther. 2024 Jan;30(1):e14486. doi: 10.1111/cns.14486. Epub 2023 Oct 13. CNS Neurosci Ther. 2024. PMID: 37830170 Free PMC article. - Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals.
Abdolmaleky HM, Zhou JR. Abdolmaleky HM, et al. Nutrients. 2023 Aug 4;15(15):3456. doi: 10.3390/nu15153456. Nutrients. 2023. PMID: 37571393 Free PMC article. Review. - Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis.
Liaqat H, Parveen A, Kim SY. Liaqat H, et al. Int J Mol Sci. 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Int J Mol Sci. 2022. PMID: 36499295 Free PMC article. Review. - Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors.
Estrada-Reyes R, Quero-Chávez DB, Alarcón-Elizalde S, Cercós MG, Trueta C, Constantino-Jonapa LA, Oikawa-Sala J, Argueta J, Cruz-Garduño R, Dubocovich ML, Benítez-King GA. Estrada-Reyes R, et al. Molecules. 2022 Sep 1;27(17):5650. doi: 10.3390/molecules27175650. Molecules. 2022. PMID: 36080418 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous