FoxO1 transcriptional activities in VEGF expression and beyond: a key regulator in functional angiogenesis? - PubMed (original) (raw)
Comment
. 2018 Jul;245(3):255-257.
doi: 10.1002/path.5088. Epub 2018 May 23.
Affiliations
- PMID: 29691864
- DOI: 10.1002/path.5088
Comment
FoxO1 transcriptional activities in VEGF expression and beyond: a key regulator in functional angiogenesis?
Bin Ren. J Pathol. 2018 Jul.
Abstract
FoxO1 has emerged as an important regulator of angiogenesis. Recent work published in this Journal shows that FoxO1 regulates VEGF expression in keratinocytes and is required for angiogenesis in wound healing. Since FoxO1 also regulates CD36 transcription, and endothelial cell differentiation and vascular maturation, this transcription factor may be essential for the formation of functional vascular networks via coupling the regulation of CD36 in vascular endothelial cells under physiological and pathological conditions. Although many outstanding questions remain to be answered, the mechanisms by which FoxO1 regulates VEGF in keratinocytes provide insight into the development of functional angiogenesis and further our understanding of vascular biology. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keywords: CD36; FoxO1; VEGF; endothelial cells; functional angiogenesis; keratinocytes; transcription; wound healing.
Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Comment on
- FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds.
Jeon HH, Yu Q, Lu Y, Spencer E, Lu C, Milovanova T, Yang Y, Zhang C, Stepanchenko O, Vafa RP, Coelho PG, Graves DT. Jeon HH, et al. J Pathol. 2018 Jul;245(3):258-264. doi: 10.1002/path.5075. Epub 2018 Apr 20. J Pathol. 2018. PMID: 29574902 Free PMC article.
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