Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression - PubMed (original) (raw)

Meta-Analysis

. 2018 May;50(5):668-681.

doi: 10.1038/s41588-018-0090-3. Epub 2018 Apr 26.

Stephan Ripke # 3 4 5, Manuel Mattheisen # 6 7 8 9, Maciej Trzaskowski # 10, Enda M Byrne 10, Abdel Abdellaoui 11, Mark J Adams 12, Esben Agerbo 8 13 14, Tracy M Air 15, Till M F Andlauer 16 17, Silviu-Alin Bacanu 18, Marie Bækvad-Hansen 8 19, Aartjan F T Beekman 20, Tim B Bigdeli 18 21, Elisabeth B Binder 16 22, Douglas R H Blackwood 12, Julien Bryois 23, Henriette N Buttenschøn 7 8 24, Jonas Bybjerg-Grauholm 8 19, Na Cai 25 26, Enrique Castelao 27, Jane Hvarregaard Christensen 6 7 8, Toni-Kim Clarke 12, Jonathan I R Coleman 28, Lucía Colodro-Conde 29, Baptiste Couvy-Duchesne 30 31, Nick Craddock 32, Gregory E Crawford 33 34, Cheynna A Crowley 35, Hassan S Dashti 3 36, Gail Davies 37, Ian J Deary 37, Franziska Degenhardt 38 39, Eske M Derks 29, Nese Direk 40 41, Conor V Dolan 11, Erin C Dunn 42 43 44, Thalia C Eley 28, Nicholas Eriksson 45, Valentina Escott-Price 46, Farnush Hassan Farhadi Kiadeh 47, Hilary K Finucane 48 49, Andreas J Forstner 38 39 50 51, Josef Frank 52, Héléna A Gaspar 28, Michael Gill 53, Paola Giusti-Rodríguez 54, Fernando S Goes 55, Scott D Gordon 56, Jakob Grove 6 7 8 57, Lynsey S Hall 12 58, Eilis Hannon 59, Christine Søholm Hansen 8 19, Thomas F Hansen 60 61 62, Stefan Herms 38 39 51, Ian B Hickie 63, Per Hoffmann 38 39 51, Georg Homuth 64, Carsten Horn 65, Jouke-Jan Hottenga 11, David M Hougaard 8 19, Ming Hu 66, Craig L Hyde 67, Marcus Ising 68, Rick Jansen 20, Fulai Jin 69 70, Eric Jorgenson 71, James A Knowles 72, Isaac S Kohane 73 74 75, Julia Kraft 5, Warren W Kretzschmar 76, Jesper Krogh 77, Zoltán Kutalik 78 79, Jacqueline M Lane 3 36 80, Yihan Li 76, Yun Li 35 54, Penelope A Lind 29, Xiaoxiao Liu 70, Leina Lu 70, Donald J MacIntyre 81 82, Dean F MacKinnon 55, Robert M Maier 30, Wolfgang Maier 83, Jonathan Marchini 84, Hamdi Mbarek 11, Patrick McGrath 85, Peter McGuffin 28, Sarah E Medland 29, Divya Mehta 30 86, Christel M Middeldorp 11 87 88, Evelin Mihailov 89, Yuri Milaneschi 20, Lili Milani 89, Jonathan Mill 59, Francis M Mondimore 55, Grant W Montgomery 10, Sara Mostafavi 90 91, Niamh Mullins 28, Matthias Nauck 92 93, Bernard Ng 91, Michel G Nivard 11, Dale R Nyholt 94, Paul F O'Reilly 28, Hogni Oskarsson 95, Michael J Owen 96, Jodie N Painter 29, Carsten Bøcker Pedersen 8 13 14, Marianne Giørtz Pedersen 8 13 14, Roseann E Peterson 18 97, Erik Pettersson 23, Wouter J Peyrot 20, Giorgio Pistis 27, Danielle Posthuma 98 99, Shaun M Purcell 100, Jorge A Quiroz 101, Per Qvist 6 7 8, John P Rice 102, Brien P Riley 18, Margarita Rivera 28 103, Saira Saeed Mirza 41, Richa Saxena 3 36 80, Robert Schoevers 104, Eva C Schulte 105 106, Ling Shen 71, Jianxin Shi 107, Stanley I Shyn 108, Engilbert Sigurdsson 109, Grant B C Sinnamon 110, Johannes H Smit 20, Daniel J Smith 111, Hreinn Stefansson 112, Stacy Steinberg 112, Craig A Stockmeier 113, Fabian Streit 52, Jana Strohmaier 52, Katherine E Tansey 114, Henning Teismann 115, Alexander Teumer 116, Wesley Thompson 8 61 117 118, Pippa A Thomson 119, Thorgeir E Thorgeirsson 112, Chao Tian 45, Matthew Traylor 120, Jens Treutlein 52, Vassily Trubetskoy 5, André G Uitterlinden 121, Daniel Umbricht 122, Sandra Van der Auwera 123, Albert M van Hemert 124, Alexander Viktorin 23, Peter M Visscher 10 30, Yunpeng Wang 8 61 117, Bradley T Webb 125, Shantel Marie Weinsheimer 8 61, Jürgen Wellmann 115, Gonneke Willemsen 11, Stephanie H Witt 52, Yang Wu 10, Hualin S Xi 126, Jian Yang 10 30, Futao Zhang 10; eQTLGen; 23andMe; Volker Arolt 127, Bernhard T Baune 15, Klaus Berger 115, Dorret I Boomsma 11, Sven Cichon 38 51 128 129, Udo Dannlowski 127, E C J de Geus 11 130, J Raymond DePaulo 55, Enrico Domenici 131, Katharina Domschke 132, Tõnu Esko 3 89, Hans J Grabe 123, Steven P Hamilton 133, Caroline Hayward 134, Andrew C Heath 102, David A Hinds 45, Kenneth S Kendler 18, Stefan Kloiber 68 135 136, Glyn Lewis 137, Qingqin S Li 138, Susanne Lucae 68, Pamela F A Madden 102, Patrik K Magnusson 23, Nicholas G Martin 56, Andrew M McIntosh 12 37, Andres Metspalu 89 139, Ole Mors 8 140, Preben Bo Mortensen 7 8 13 14, Bertram Müller-Myhsok 16 17 141, Merete Nordentoft 8 142, Markus M Nöthen 38 39, Michael C O'Donovan 96, Sara A Paciga 143, Nancy L Pedersen 23, Brenda W J H Penninx 20, Roy H Perlis 43 144, David J Porteous 119, James B Potash 145, Martin Preisig 27, Marcella Rietschel 52, Catherine Schaefer 71, Thomas G Schulze 52 55 106 146 147, Jordan W Smoller 42 43 44, Kari Stefansson 112 148, Henning Tiemeier 41 149 150, Rudolf Uher 151, Henry Völzke 116, Myrna M Weissman 85 152, Thomas Werge 8 61 153, Ashley R Winslow 154 155, Cathryn M Lewis 28 156, Douglas F Levinson 157, Gerome Breen 28 158, Anders D Børglum 6 7 8, Patrick F Sullivan 159 160 161; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium