A novel and simply calculated nutritional index serves as a useful prognostic indicator in patients with coronary artery disease - PubMed (original) (raw)

Observational Study

doi: 10.1016/j.ijcard.2018.02.039.

Hiroshi Iwata 2, Hideki Wada 1, Takehiro Funamizu 1, Jun Shitara 1, Hirohisa Endo 1, Ryo Naito 3, Hirokazu Konishi 4, Shuta Tsuboi 4, Manabu Ogita 4, Tomotaka Dohi 1, Takatoshi Kasai 1, Shinya Okazaki 1, Kikuo Isoda 1, Katsumi Miyauchi 1, Hiroyuki Daida 1

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Observational Study

A novel and simply calculated nutritional index serves as a useful prognostic indicator in patients with coronary artery disease

Shinichiro Doi et al. Int J Cardiol. 2018.

Abstract

Objective: No nutritional index has been firmly established yet in patients with coronary artery disease (CAD). In this study, we propose a simple to calculate nutritional indicator in patients who underwent percutaneous coronary intervention (PCI) by using parameters routinely measured in CAD and evaluated its prognostic implication.

Methods: This study is a retrospective observational analysis of a prospective database. The subjects were consecutive 3567 patients underwent their first PCI between 2000 and 2013 at Juntendo University Hospital in Tokyo. The median of the follow-up period was 6.3 years (range: 0-13.6 years). The novel nutritional index was calculated by the formula; Triglycerides (TG) × Total Cholesterol (TC) × Body Weight (BW) Index (TCBI) = TG × TC × BW / 1000 (TG and TC: mg/dl, and BW: kg).

Results: The Spearman non-parametric correlation coefficient between TCBI and the most often used conventional nutritional index, Geriatric Nutritional Risk Index (GNRI), was 0.355, indicating modest correlation. Moreover, Unadjusted Kaplan-Meier analysis showed higher all-cause mortality, cardiovascular mortality, and cancer mortality in patients with low TCBI. Consistently, elevation of TCBI was associated with reduced all-cause (hazard ratio: 0.86, 95%CI: 0.77-0.96, p < 0.001), cardiovascular (0.78, 0.66-0.92, p = 0.003), and cancer mortality (0.76, 0.58-0.99, p = 0.041) in patients after PCI by multivariate Cox proportional hazard analyses.

Conclusion: TCBI, a novel and easy to calculate nutrition index, is a useful prognostic indicator in patients with CAD.

Keywords: Coronary artery disease; Nutritional index; Prognosis.

Copyright © 2018 Elsevier B.V. All rights reserved.

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