Protein Folding: A Perspective from Theory and Experiment - PubMed (original) (raw)
Review
Protein Folding: A Perspective from Theory and Experiment
Christopher M Dobson et al. Angew Chem Int Ed Engl. 1998.
Abstract
The mechanism of protein folding (represented schematically below) is one of the most fascinating problems in the field of chemical reactions. This review presents the progess made recently in understanding key elements of this reaction and describes a solution to the often quoted Levinthal Paradox.
Keywords: Kinetics; Molecular dynamics; Protein folding; Proteins; Structure elucidation.
© 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.
Similar articles
- What is paradoxical about Levinthal paradox?
Rooman M, Dehouck Y, Kwasigroch JM, Biot C, Gilis D. Rooman M, et al. J Biomol Struct Dyn. 2002 Dec;20(3):327-9. doi: 10.1080/07391102.2002.10506850. J Biomol Struct Dyn. 2002. PMID: 12437370 - Protein folding: from the levinthal paradox to structure prediction.
Honig B. Honig B. J Mol Biol. 1999 Oct 22;293(2):283-93. doi: 10.1006/jmbi.1999.3006. J Mol Biol. 1999. PMID: 10550209 Review. - Cunning simplicity of a hierarchical folding.
Finkelstein AV. Finkelstein AV. J Biomol Struct Dyn. 2002 Dec;20(3):311-3. doi: 10.1080/07391102.2002.10506846. J Biomol Struct Dyn. 2002. PMID: 12437366 - Interpreting the folding kinetics of helical proteins.
Zhou Y, Karplus M. Zhou Y, et al. Nature. 1999 Sep 23;401(6751):400-3. doi: 10.1038/43937. Nature. 1999. PMID: 10517642 - Cooperativity, local-nonlocal coupling, and nonnative interactions: principles of protein folding from coarse-grained models.
Chan HS, Zhang Z, Wallin S, Liu Z. Chan HS, et al. Annu Rev Phys Chem. 2011;62:301-26. doi: 10.1146/annurev-physchem-032210-103405. Annu Rev Phys Chem. 2011. PMID: 21453060 Review.
Cited by
- New insights into the folding of a β-sheet miniprotein in a reduced space of collective hydrogen bond variables: application to a hydrodynamic analysis of the folding flow.
Kalgin IV, Caflisch A, Chekmarev SF, Karplus M. Kalgin IV, et al. J Phys Chem B. 2013 May 23;117(20):6092-105. doi: 10.1021/jp401742y. Epub 2013 May 15. J Phys Chem B. 2013. PMID: 23621790 Free PMC article. - Combinatorial pattern discovery approach for the folding trajectory analysis of a beta-hairpin.
Parida L, Zhou R. Parida L, et al. PLoS Comput Biol. 2005 Jun;1(1):e8. doi: 10.1371/journal.pcbi.0010008. Epub 2005 Jun 24. PLoS Comput Biol. 2005. PMID: 16103909 Free PMC article. - Understanding beta-hairpin formation.
Dinner AR, Lazaridis T, Karplus M. Dinner AR, et al. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9068-73. doi: 10.1073/pnas.96.16.9068. Proc Natl Acad Sci U S A. 1999. PMID: 10430896 Free PMC article. - A simple model for calculating the kinetics of protein folding from three-dimensional structures.
Muñoz V, Eaton WA. Muñoz V, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11311-6. doi: 10.1073/pnas.96.20.11311. Proc Natl Acad Sci U S A. 1999. PMID: 10500173 Free PMC article. - Macromolecular dynamics in red blood cells investigated using neutron spectroscopy.
Stadler AM, van Eijck L, Demmel F, Artmann G. Stadler AM, et al. J R Soc Interface. 2011 Apr 6;8(57):590-600. doi: 10.1098/rsif.2010.0306. Epub 2010 Aug 25. J R Soc Interface. 2011. PMID: 20739313 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources