Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis - PubMed (original) (raw)

. 2018 Apr 6;9(8):1518-1526.

doi: 10.7150/jca.22691. eCollection 2018.

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Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis

Kaihua Gou et al. J Cancer. 2018.

Abstract

Minichromosome maintenance proteins (MCM) played a critical role in replication and cell cycle progression. However, their prognostic roles in cancer remain controversial. Therefore, we performed a meta-analysis to investigate the prognostic value of MCMs in cancers. Totally 31 eligible articles with 7653 cancer patients were included in this meta-analysis. We evaluated the relationship between MCMs expression and overall survival (OS) in various cancer patients by using pooled hazard ratios (HRs) and risk ratios (RRs) with 95% confidence intervals (CIs). The meta-analysis showed that carriers with high expression of MCM5 and MCM7 were significantly associated with short OS for pooled HR (HR=1.04, 95% CI=1.01-1.08, P=0.020, HR=1.78, 95% CI=1.04-3.02, P=0.035, respectively). For pooled RR, individuals with increased MCM2 and MCM7 expression were significantly correlated with poor OS (RR=2.30, 95% CI=1.14-4.63, P=0.019; RR=3.52, 95% CI=2.01-6.18, P<0.001, respectively). The findings suggest that high expression of MCM2, MCM5 and MCM7 might serve as predictive biomarkers for poor prognosis in cancers.

Keywords: MCM; meta-analysis; prognosis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1

Figure 1

Flow diagram of studies selection procedure

Figure 2

Figure 2

Forest plot of HR for the association between MCM2 and OS (H/P vs. L/N).

Figure 3

Figure 3

Forest plot of RR for the association between MCM2 and OS (H/P vs. L/N).

Figure 4

Figure 4

Forest plot of HR for the association between MCM5 and OS (H vs. L).

Figure 5

Figure 5

Forest plot of HR for the association between MCM7 and OS (H/P vs. L/N).

Figure 6

Figure 6

Forest plot of RR for the association between MCM7 and OS (H/P vs. L/N).

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References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinicians. 2015;65(2):87–108. - PubMed
    1. Ferrandina G, Lauriola L, Distefano MG, Zannoni GF, Gessi M, Legge F, Maggiano N, Mancuso S, Capelli A, Scambia G. et al. Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2002;20(4):973–981. - PubMed
    1. Inoue K, Slaton JW, Karashima T, Yoshikawa C, Shuin T, Sweeney P, Millikan R, Dinney CP. The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy. Clinical cancer research: an official journal of the American Association for Cancer Research. 2000;6(12):4866–4873. - PubMed
    1. Margulis V, Shariat SF, Matin SF, Kamat AM, Zigeuner R, Kikuchi E, Lotan Y, Weizer A, Raman JD, Wood CG. Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer. 2009;115(6):1224–1233. - PubMed
    1. Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168(6):2395–2400. - PubMed

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