Antibacterial activity of Thymus vulgaris essential oil alone and in combination with cefotaxime against blaESBL producing multidrug resistant Enterobacteriaceae isolates - PubMed (original) (raw)
. 2019 Sep;33(18):2647-2654.
doi: 10.1080/14786419.2018.1466124. Epub 2018 May 4.
Teresa Gervasi 3, Vito Pellizzeri 3, Mária Pľuchtová 4, Hassiba Tali-Maama 5, Farida Assaous 5, Badia Guettou 5, Kheira Rahal 5, Daniela Gruľová 4, Giacomo Dugo 3 6, Andreana Marino 7, Meriem-Hind Ben-Mahdi 2 8
Affiliations
- PMID: 29726697
- DOI: 10.1080/14786419.2018.1466124
Antibacterial activity of Thymus vulgaris essential oil alone and in combination with cefotaxime against _bla_ESBL producing multidrug resistant Enterobacteriaceae isolates
Qada Benameur et al. Nat Prod Res. 2019 Sep.
Abstract
The aim was to evaluate the susceptibility of _bla_ESBL producing Enterobacteriaceae to Slovakian Thymus vulgaris essential oil (TVEO) alone and in combination with cefotaxime (CTX). TVEO composition was determined by gas chromatograph-mass spectrometer (GC/MS). Susceptibility to 21 antibiotics was determined by disc diffusion assay. Genes characterization for resistance to β-lactams was accomplished by polymerase chain reaction (PCR). The antibacterial activity was investigated by standard methods. The synergistic interaction was determined by checkerboard test. Thymol (34.5%), p-cymene (22.27%) and linalool (5.35%) were the major components present in the TVEO. The identified strains were multi-drug resistant (MDR). TVEO showed high activity against all MDR strains, including _bla_ESBL producing isolates, with inhibition zones and MIC values in the range of 24-40 mm/10μL and 2.87-11.5 μg/mL, respectively. TVEO in combination with CTX showed a synergistic action against _bla_SHV-12 producing Escherichia coli (FICI 0.28) and an additive effect vs ESBL producing Enterobacter cloacae (FICI 0.987).
Keywords: ESBL; antibacterial-resistance; essential oil; synergism.
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