Interaction at a distance between lambda repressors disrupts gene activation - PubMed (original) (raw)
. 1988 Nov 24;336(6197):353-7.
doi: 10.1038/336353a0.
Affiliations
- PMID: 2973565
- DOI: 10.1038/336353a0
Interaction at a distance between lambda repressors disrupts gene activation
A Hochschild et al. Nature. 1988.
Abstract
The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.
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