Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle - PubMed (original) (raw)

Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle

M Mackett et al. Science. 1985.

Abstract

Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.

PubMed Disclaimer

Similar articles

• Protection against lethal vaccinia virus challenge by using an attenuated matrix protein mutant vesicular stomatitis virus vaccine vector expressing poxvirus antigens.
  Braxton CL, Puckett SH, Mizel SB, Lyles DS. Braxton CL, et al. J Virol. 2010 Apr;84(7):3552-61. doi: 10.1128/JVI.01572-09. Epub 2010 Jan 20. J Virol. 2010. PMID: 20089648 Free PMC article.
• Immune responses of cattle and mice to the G glycoprotein of vesicular stomatitis virus.
  Yilma T, Breeze RG, Ristow S, Gorham JR, Leib SR. Yilma T, et al. Adv Exp Med Biol. 1985;185:101-15. doi: 10.1007/978-1-4684-7974-4_6. Adv Exp Med Biol. 1985. PMID: 3000147
• Recombinant vesicular stomatitis (Indiana) virus expressing New Jersey and Indiana glycoproteins induces neutralizing antibodies to each serotype in swine, a natural host.
  Martinez I, Barrera JC, Rodriguez LL, Wertz GW. Martinez I, et al. Vaccine. 2004 Sep 28;22(29-30):4035-43. doi: 10.1016/j.vaccine.2004.03.065. Vaccine. 2004. PMID: 15364454
• Genetically engineered vaccines for animal viral diseases.
  Yilma T. Yilma T. J Am Vet Med Assoc. 1994 May 15;204(10):1606-15. J Am Vet Med Assoc. 1994. PMID: 8050940 Review. No abstract available.
• Vesicular diseases: recent advances and concepts of control.
  Watson WA. Watson WA. Can Vet J. 1981 Oct;22(10):311-20. Can Vet J. 1981. PMID: 6282431 Free PMC article. Review.

Cited by

• Immunization with a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: long-term protection and effect of revaccination.
  Rooney JF, Wohlenberg C, Cremer KJ, Moss B, Notkins AL. Rooney JF, et al. J Virol. 1988 May;62(5):1530-4. doi: 10.1128/JVI.62.5.1530-1534.1988. J Virol. 1988. PMID: 2833606 Free PMC article.
• Use of vaccinia virus to express biopharmaceutical products.
  Hruby DE, Thomas G. Hruby DE, et al. Pharm Res. 1987 Apr;4(2):92-7. doi: 10.1023/a:1016454600151. Pharm Res. 1987. PMID: 3334412 Review.
• Vaccinia virus recombinants expressing rabiesvirus glycoprotein protect against rabies.
  Esposito J, Brechling K, Baer G, Moss B. Esposito J, et al. Virus Genes. 1987 Nov;1(1):7-21. doi: 10.1007/BF00125682. Virus Genes. 1987. PMID: 3508340
• The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells.
  Jones E, Price DA, Dahm-Vicker M, Cerundolo V, Klenerman P, Gallimore A. Jones E, et al. Immunology. 2003 May;109(1):68-75. doi: 10.1046/j.1365-2567.2003.01636.x. Immunology. 2003. PMID: 12709019 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information