The herpes simplex virus amplicon: analyses of cis-acting replication functions - PubMed (original) (raw)
The herpes simplex virus amplicon: analyses of cis-acting replication functions
R R Spaete et al. Proc Natl Acad Sci U S A. 1985 Feb.
Abstract
Previous studies have shown that defective virus vectors (amplicons) derived from herpes simplex viruses could be efficiently propagated in virus stocks in the presence of trans-acting helper virus functions. The present study established that two separate cis-acting functions--a DNA replication origin and a cleavage/packaging signal--are required for amplicon propagation. Using deleted derivatives of cloned amplicons, we mapped one of the viral DNA replication origins (ori-2 or oriL) at coordinate 0.422 of the standard HSV-1 genome and at an equivalent position within the HSV-2 genome.
Similar articles
- Herpes simplex virus amplicon: effect of size on replication of constructed defective genomes containing eucaryotic DNA sequences.
Kwong AD, Frenkel N. Kwong AD, et al. J Virol. 1984 Sep;51(3):595-603. doi: 10.1128/JVI.51.3.595-603.1984. J Virol. 1984. PMID: 6088785 Free PMC article. - The history of the HSV amplicon: from naturally occurring defective genomes to engineered amplicon vectors.
Frenkel N. Frenkel N. Curr Gene Ther. 2006 Jun;6(3):277-301. doi: 10.2174/156652306777591992. Curr Gene Ther. 2006. PMID: 16787181 Review. - Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA.
Deiss LP, Chou J, Frenkel N. Deiss LP, et al. J Virol. 1986 Sep;59(3):605-18. doi: 10.1128/JVI.59.3.605-618.1986. J Virol. 1986. PMID: 3016323 Free PMC article. - Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome.
Saeki Y, Fraefel C, Ichikawa T, Breakefield XO, Chiocca EA. Saeki Y, et al. Mol Ther. 2001 Apr;3(4):591-601. doi: 10.1006/mthe.2001.0294. Mol Ther. 2001. PMID: 11319922 - Minireview: the herpes simplex virus amplicon--a versatile defective virus vector.
Frenkel N, Singer O, Kwong AD. Frenkel N, et al. Gene Ther. 1994;1 Suppl 1:S40-6. Gene Ther. 1994. PMID: 8542394 Review.
Cited by
- The alpha sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes.
Spaete RR, Mocarski ES. Spaete RR, et al. J Virol. 1985 Jun;54(3):817-24. doi: 10.1128/JVI.54.3.817-824.1985. J Virol. 1985. PMID: 2987533 Free PMC article. - Nucleotide sequence and structural features of a novel US-a junction present in a defective herpes simplex virus genome.
Mocarski ES, Deiss LP, Frenkel N. Mocarski ES, et al. J Virol. 1985 Jul;55(1):140-6. doi: 10.1128/JVI.55.1.140-146.1985. J Virol. 1985. PMID: 2989551 Free PMC article. - Virus-based gene delivery systems.
Mah C, Byrne BJ, Flotte TR. Mah C, et al. Clin Pharmacokinet. 2002;41(12):901-11. doi: 10.2165/00003088-200241120-00001. Clin Pharmacokinet. 2002. PMID: 12222993 Review. - Herpes simplex virus type 1 oriL is not required for virus replication or for the establishment and reactivation of latent infection in mice.
Polvino-Bodnar M, Orberg PK, Schaffer PA. Polvino-Bodnar M, et al. J Virol. 1987 Nov;61(11):3528-35. doi: 10.1128/JVI.61.11.3528-3535.1987. J Virol. 1987. PMID: 2822960 Free PMC article.
References
- J Gen Virol. 1977 Mar;34(3):507-22 - PubMed
- Cell. 1979 Mar;16(3):481-94 - PubMed
- Proc Natl Acad Sci U S A. 1981 Feb;78(2):742-6 - PubMed
- Proc Natl Acad Sci U S A. 1981 Nov;78(11):7047-51 - PubMed
- Proc Natl Acad Sci U S A. 1982 Mar;79(5):1423-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources