Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex - PubMed (original) (raw)
Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex
G C Brown et al. Biochem J. 1985.
Abstract
The redox states of exogenously added ubiquinone-2 and cytochrome c, and the protonmotive force (delta p) of rat liver mitochondria were measured as the respiration rate was titrated with the uncoupler carbonyl cyanide p-trifluoromethoxyphenyl-hydrazone. The force ratio delta Eh/delta p across the bc1 complex was close to 1:1 in State 4, indicating an H+/e- stoichiometry of 1:1 for the cytochrome bc1 complex, excluding protons moved by pool ubiquinone. Assuming a constant stoichiometry the rate of electron transport increased linearly with the disequilibrium (delta Eh - delta p) across the complex.
Similar articles
- Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.
Brand MD, Al-Shawi MK, Brown GC, Price BD. Brand MD, et al. Biochem J. 1985 Jan 15;225(2):407-11. doi: 10.1042/bj2250407. Biochem J. 1985. PMID: 2983671 Free PMC article. - The inhibition of proton translocation in the mitochondrial bc1 region by dicyclohexylcarbodiimide.
Esposti MD, Saus JB, Timoneda J, Bertoli E, Lenaz G. Esposti MD, et al. FEBS Lett. 1982 Oct 4;147(1):101-5. doi: 10.1016/0014-5793(82)81020-x. FEBS Lett. 1982. PMID: 6291995 No abstract available. - Electron and proton transfers through quinones and cytochrome bc complexes.
Rich PR. Rich PR. Biochim Biophys Acta. 1984 Apr 9;768(1):53-79. doi: 10.1016/0304-4173(84)90007-7. Biochim Biophys Acta. 1984. PMID: 6322844 Review. No abstract available. - Structural and functional features of the interaction of cytochrome c with complex III and cytochrome c oxidase.
Capaldi RA, Darley-Usmar V, Fuller S, Millett F. Capaldi RA, et al. FEBS Lett. 1982 Feb 8;138(1):1-7. doi: 10.1016/0014-5793(82)80382-7. FEBS Lett. 1982. PMID: 6279436 Review. No abstract available.
Cited by
- Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs.
Uno S, Harkiss AH, Chowdhury R, Caldwell ST, Prime TA, James AM, Gallagher B, Prudent J, Hartley RC, Murphy MP. Uno S, et al. Chembiochem. 2023 Jun 1;24(11):e202200774. doi: 10.1002/cbic.202200774. Epub 2023 May 4. Chembiochem. 2023. PMID: 36917207 Free PMC article. - Intravenous Transplantation of an Ischemic-specific Peptide-TPP-mitochondrial Compound Alleviates Myocardial Ischemic Reperfusion Injury.
Sun X, Chen H, Gao R, Qu Y, Huang Y, Zhang N, Hu S, Fan F, Zou Y, Hu K, Chen Z, Ge J, Sun A. Sun X, et al. ACS Nano. 2023 Jan 10;17(2):896-909. doi: 10.1021/acsnano.2c05286. Online ahead of print. ACS Nano. 2023. PMID: 36625783 Free PMC article. - Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells.
Sharpe MA, Baskin DS, Pichumani K, Ijare OB, Helekar SA. Sharpe MA, et al. Front Oncol. 2021 Nov 10;11:768758. doi: 10.3389/fonc.2021.768758. eCollection 2021. Front Oncol. 2021. PMID: 34858847 Free PMC article. - Modelling mitochondrial ROS production by the respiratory chain.
Mazat JP, Devin A, Ransac S. Mazat JP, et al. Cell Mol Life Sci. 2020 Feb;77(3):455-465. doi: 10.1007/s00018-019-03381-1. Epub 2019 Nov 20. Cell Mol Life Sci. 2020. PMID: 31748915 Free PMC article. Review. - Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase.
Bazil JN. Bazil JN. Biophys J. 2017 Oct 3;113(7):1599-1612. doi: 10.1016/j.bpj.2017.08.018. Biophys J. 2017. PMID: 28978450 Free PMC article.
References
- Biochem J. 1977 May 15;164(2):305-22 - PubMed
- Eur J Biochem. 1973 Dec 17;40(2):431-7 - PubMed
- J Membr Biol. 1979 Aug;49(2):105-21 - PubMed
- J Biol Chem. 1979 Nov 25;254(22):11555-60 - PubMed
- Biochim Biophys Acta. 1979 Dec 13;549(3-4):225-53 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources