Forked, gypsys, and suppressors in Drosophila - PubMed (original) (raw)
Forked, gypsys, and suppressors in Drosophila
S M Parkhurst et al. Cell. 1985 Jun.
Abstract
We have isolated DNA sequences defining the forked locus of Drosophila. All the alleles belonging to the right pseudoallelic series of M. M. Green map within a 5.4 kb DNA fragment that encodes four transcripts. These RNAs are only expressed in 2-4 day old pupae and their accumulation is affected by mutations at the forked locus. Also, homozygous mutations at the unlinked suppressor loci su(Hw) and su(f) cause the accumulation of these RNAs to return to the normal wild-type levels. The gypsy transposable element, which causes the mutant phenotype in the suppressible forked alleles, encodes a transcript that is maximally expressed in 2-3 day old pupae, the same time in development as transcription of the forked RNAs. We propose a model to explain the mutagenic effect of gypsy based on the influence of promoter elements in the long terminal repeats of the transposon on the transcription from other promoters located nearby.
Similar articles
- The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.
Parkhurst SM, Harrison DA, Remington MP, Spana C, Kelley RL, Coyne RS, Corces VG. Parkhurst SM, et al. Genes Dev. 1988 Oct;2(10):1205-15. doi: 10.1101/gad.2.10.1205. Genes Dev. 1988. PMID: 2462523 - Mutations at the suppressor of forked locus increase the accumulation of gypsy-encoded transcripts in Drosophila melanogaster.
Parkhurst SM, Corces VG. Parkhurst SM, et al. Mol Cell Biol. 1986 Jun;6(6):2271-4. doi: 10.1128/mcb.6.6.2271-2274.1986. Mol Cell Biol. 1986. PMID: 3023926 Free PMC article. - Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.
Modolell J, Bender W, Meselson M. Modolell J, et al. Proc Natl Acad Sci U S A. 1983 Mar;80(6):1678-82. doi: 10.1073/pnas.80.6.1678. Proc Natl Acad Sci U S A. 1983. PMID: 6300868 Free PMC article. - Interactions of retrotransposons with the host genome: the case of the gypsy element of Drosophila.
Corces VG, Geyer PK. Corces VG, et al. Trends Genet. 1991 Mar;7(3):86-90. doi: 10.1016/0168-9525(91)90277-W. Trends Genet. 1991. PMID: 1851585 Review. - The bithorax complex of Drosophila: an overview.
Morata G, Sánchez-Herrero E, Casanova J. Morata G, et al. Cell Differ. 1986 Mar;18(2):67-78. doi: 10.1016/0045-6039(86)90001-1. Cell Differ. 1986. PMID: 2420475 Review. No abstract available.
Cited by
- Developmental genetics of a P element induced allele of suppressor-of-forked in Drosophila melanogaster.
Girton JR, Langner K, Cejka N. Girton JR, et al. Rouxs Arch Dev Biol. 1986 Jul;195(5):334-337. doi: 10.1007/BF00376066. Rouxs Arch Dev Biol. 1986. PMID: 28306058 - The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning.
Botas J, Cabrera CV, Garcia-Bellido A. Botas J, et al. Rouxs Arch Dev Biol. 1988 Dec;197(7):424-434. doi: 10.1007/BF00398994. Rouxs Arch Dev Biol. 1988. PMID: 28305750 - The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis.
Lu Q, Adler PN. Lu Q, et al. PLoS One. 2015 Mar 2;10(3):e0115623. doi: 10.1371/journal.pone.0115623. eCollection 2015. PLoS One. 2015. PMID: 25730111 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases