Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper - PubMed (original) (raw)

Review

doi: 10.1016/j.phrs.2018.05.015. Epub 2018 May 30.

Carlo M Barbagallo 2, Arrigo F G Cicero 3, Alberto Corsini 4, Enzo Manzato 5, Bruno Trimarco 6, Franco Bernini 7, Francesco Visioli 8, Alfio Bianchi 9, Giuseppe Canzone 10, Claudio Crescini 11, Saula de Kreutzenberg 12, Nicola Ferrara 13, Marco Gambacciani 14, Andrea Ghiselli 15, Carla Lubrano 16, Giuseppe Marelli 17, Walter Marrocco 18, Vincenzo Montemurro 19, Damiano Parretti 20, Roberto Pedretti 21, Francesco Perticone 22, Roberto Stella 23, Franca Marangoni 24

Affiliations

• PMID: 29859248
• DOI: 10.1016/j.phrs.2018.05.015

Review

Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

Andrea Poli et al. Pharmacol Res. 2018 Aug.

Abstract

Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").

Keywords: Cardiovascular risk; Cholesterol; Food supplements; Functional foods; LDL cholesterol; Primary prevention.

Copyright © 2018 Elsevier Ltd. All rights reserved.

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