Rapid detection and monitoring of human coronavirus infections - PubMed (original) (raw)

Rapid detection and monitoring of human coronavirus infections

A H L Bruning et al. New Microbes New Infect. 2018.

Abstract

Human coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a newly developed assay for rapid detection of CoV OC43 infections. Antigen positivity lasted 3 to 6 days in secondary infections and 13 days in primary infection. CoV infections are clinically diverse, are common, and cannot be diagnosed from clinical symptoms alone.

Keywords: Human coronavirus; point-of-care test; rapid antigen test; rapid detection; respiratory tract infection.

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Figures

Fig. 1

Fig. 1

Detection of coronavirus antigen by mariPOC in six patients with respiratory tract infection symptoms. Results are shown from date of symptom onset. Bars marked with ‘NEG’ display samples with a mariPOC signal below cutoff for positive finding. One sample obtained in middle of positivity period (marked with asterisk) was also negative by PCR, suggesting that sample collection was unsuccessful.

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