Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group - PubMed (original) (raw)

. 2018 May 21;3(2):175-192.

doi: 10.1002/epi4.12225. eCollection 2018 Jun.

Beth A Zupec-Kania 2, Stéphane Auvin 3, Karen R Ballaban-Gil 4, A G Christina Bergqvist 5, Robyn Blackford 6, Jeffrey R Buchhalter 7, Roberto H Caraballo 8, J Helen Cross 9, Maria G Dahlin 10, Elizabeth J Donner 11, Orkide Guzel 12, Rana S Jehle 13, Joerg Klepper 14, Hoon-Chul Kang 15, Danielle A Lambrechts 16, Y M Christiana Liu 17, Janak K Nathan 18, Douglas R Nordli Jr 19, Heidi H Pfeifer 20, Jong M Rho 21, Ingrid E Scheffer 22, Suvasini Sharma 23, Carl E Stafstrom 24, Elizabeth A Thiele 20, Zahava Turner 25, Maria M Vaccarezza 26, Elles J T M van der Louw 27, Pierangelo Veggiotti 28, James W Wheless 29, Elaine C Wirrell 30; Charlie Foundation; Matthew's Friends; Practice Committee of the Child Neurology Society

Affiliations

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group

Eric H Kossoff et al. Epilepsia Open. 2018.

Abstract

Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

Keywords: Children; Diet; Epilepsy; Guideline; Ketogenic.

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